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  3. PRC1

PRC1 (Protein regulator of cytokinesis 1)

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The Function of PRC1

Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436).

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Protein names

Recommended name:

Protein regulator of cytokinesis 1

PRC1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2290203 (PRC1) ??
  2. RS8042680 (PRC1) ??

Top Gene-Substance Interactions

Substances That Increase PRC1

Substances Interaction Organism Category

Substances That Decrease PRC1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • STAT3
  • Nkx2-5
  • ARP-1
  • E2F-1
  • E47
  • LCR-F1

Tissue specificity:

Overexpressed in bladder cancer cells (PubMed:17409436).

Molecular Function:

  • Identical Protein Binding
  • Kinesin Binding
  • Protein Kinase Binding

Biological Processes:

  • Cytokinesis
  • Microtubule Bundle Formation
  • Mitotic Spindle Elongation
  • Positive Regulation Of Cell Proliferation
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| ASE1| anaphase spindle elongation 1 homolog| AS27_14936| D623_10013235| D7Ertd348e| I79_023385| M91_16074| MDA_GLEAN10006768| N300_02994| N302_04934| N305_13069| N308_01466| N312_10713| N322_06665| N324_09263| N327_11178| N329_04262| N330_09020| N333_05384| N334_09097| N335_05799| N336_05668| N339_04453| N340_07939| N341_04964| PANDA_008493| protein regulating cytokinesis 1| regulator of cytokinesis 1| TREES_T100018743| Y956_09617| Z169_14371| prc1

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