The Function of PRC1
Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436).
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Protein names
Recommended name:
Protein regulator of cytokinesis 1- RS2290203 (PRC1) ??
- RS8042680 (PRC1) ??
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Top Gene-Substance Interactions
Substances That Increase PRC1
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Substances That Decrease PRC1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Overexpressed in bladder cancer cells (PubMed:17409436).
Molecular Function:
Biological Processes:
- Mitotic Spindle Elongation
- Cytokinesis
- Microtubule Bundle Formation
- Positive Regulation Of Cell Proliferation