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  3. PPP3R1

PPP3R1 (Protein phosphatase 3 regulatory subunit B, alpha)

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The Function of PPP3R1

Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.

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Protein names

Recommended name:

Calcineurin subunit B type 1

Alternative name(s):

Protein phosphatase 2B regulatory subunit 1
Protein phosphatase 3 regulatory subunit B alpha isoform 1

PPP3R1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1868402 (PPP3R1) ??

Top Gene-Substance Interactions

PPP3R1 Interacts with These Diseases

Disease Score

Substances That Increase PPP3R1

Substances Interaction Organism Category

Substances That Decrease PPP3R1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha
  • GR-beta

Gene Pathways:

  • Immune System
  • MAPK signaling pathway
  • Signal Transduction
  • Wnt signaling pathway
  • Calcium signaling pathway
  • Natural killer cell mediated cytotoxicity
  • Tuberculosis
  • Apoptosis
  • Amyotrophic lateral sclerosis (ALS)
  • Axon guidance
  • T cell receptor signaling pathway
  • Alzheimer's disease
  • Apoptosis
  • B cell receptor signaling pathway
  • Glutamatergic synapse
  • Oocyte meiosis
  • VEGF signaling pathway
  • Long-term potentiation

Molecular Function:

  • Calcium-Dependent Protein Serine/Threonine Phosphatase Activity
  • Calcium Ion Binding
  • Calmodulin Binding
  • Protein Domain Specific Binding

Biological Processes:

  • Calcineurin-Nfat Signaling Cascade
  • Fc-Epsilon Receptor Signaling Pathway
  • Positive Regulation Of Nfat Protein Import Into Nucleus
  • Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Wnt Signaling Pathway, Calcium Modulating Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_04157| AS27_09374| AS28_11139| calcineurin B| Calcineurin B subunit isoform 1-like protein| calcineurin B, type I (19kDa)| calcineurin subunit B type 1| CALNB1| CaNB1| CB1_001866030| CNB| CNB1| H920_17488| I79_008944| M91_09586| M959_10797| MCIP1| N300_08751| N301_00723| N302_10457| N303_01239| N305_03658| N306_11323| N307_10364| N308_08545| N309_10889| N310_07550| N311_00390| N312_06027| N320_03958| N321_13705| N322_13501| N324_06577| N325_06887| N326_02877| N327_11861| N328_03115| N329_08920| N330_02301| N331_06843| N332_10696| N334_12585| N335_06751| N336_01226| N339_02646| N340_04001| PAL_GLEAN10021183| PANDA_014833| PP2B beta 1| protein phospatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)| protein phospatase 3, regulatory subunit B, alpha isoform,type 1| protein phosphatase 2B regulatory subunit 1| protein phosphatase 2B regulatory subunit B alpha| protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)| protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I)| protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform| protein phosphatase 3 regulatory subunit B alpha| protein phosphatase 3, regulatory subunit B, alpha| protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)| TREES_T100006761| Y1Q_030228| Y956_07389| Z169_11153| ppp3r1

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