The Function of PPP3R1
Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
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Protein names
Recommended name:
Calcineurin subunit B type 1Alternative name(s):
Protein phosphatase 2B regulatory subunit 1Protein phosphatase 3 regulatory subunit B alpha isoform 1
- RS1868402 (PPP3R1) ??
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Top Gene-Substance Interactions
PPP3R1 Interacts with These Diseases
| Disease | Score |
Substances That Increase PPP3R1
| Substances | Interaction | Organism | Category |
Substances That Decrease PPP3R1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
- Immune System
- MAPK signaling pathway
- Signal Transduction
- Wnt signaling pathway
- Calcium signaling pathway
- Natural killer cell mediated cytotoxicity
- Tuberculosis
- Apoptosis
- Amyotrophic lateral sclerosis (ALS)
- Axon guidance
- T cell receptor signaling pathway
- Alzheimer's disease
- Apoptosis
- B cell receptor signaling pathway
- Glutamatergic synapse
- Oocyte meiosis
- VEGF signaling pathway
- Long-term potentiation
Molecular Function:
- Calcium-Dependent Protein Serine/Threonine Phosphatase Activity
- Calcium Ion Binding
- Calmodulin Binding
- Protein Domain Specific Binding
Biological Processes:
- Calcineurin-Nfat Signaling Cascade
- Fc-Epsilon Receptor Signaling Pathway
- Positive Regulation Of Nfat Protein Import Into Nucleus
- Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Wnt Signaling Pathway, Calcium Modulating Pathway