The Function of PPP2R4
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A.
Protein names
Recommended name:
Serine/threonine-protein phosphatase 2A activatorShort name:
PTPAAlternative name(s):
PP2A, subunit B', PR53 isoformPhosphotyrosyl phosphatase activator
Serine/threonine-protein phosphatase 2A regulatory subunit 4
Serine/threonine-protein phosphatase 2A regulatory subunit B'
- RS10988217 (PPP2R4) ??
- RS17481720 (PPP2R4) ??
- RS7849270 (PPP2R4) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
Substances That Increase PPP2R4
| Substances | Interaction | Organism | Category |
Substances That Decrease PPP2R4
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Widely expressed.
Molecular Function:
- Atp Binding
- Peptidyl-Prolyl Cis-Trans Isomerase Activity
- Protein Heterodimerization Activity
- Protein Homodimerization Activity
- Protein Phosphatase 2a Binding
- Protein Phosphatase Type 2a Regulator Activity
- Protein Tyrosine Phosphatase Activator Activity
- Receptor Binding
Biological Processes:
- Mitotic Spindle Organization In Nucleus
- Negative Regulation Of Phosphoprotein Phosphatase Activity
- Negative Regulation Of Protein Dephosphorylation
- Positive Regulation Of Apoptotic Process
- Positive Regulation Of Phosphoprotein Phosphatase Activity
- Positive Regulation Of Protein Dephosphorylation
- Regulation Of Phosphoprotein Phosphatase Activity