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  3. PPP1R13L

PPP1R13L (Protein phosphatase 1 regulatory subunit 13 like)

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The Function of PPP1R13L

Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis.

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Protein names

Recommended name:

RelA-associated inhibitor

Alternative name(s):

Inhibitor of ASPP protein
Protein iASPP
NFkB-interacting protein 1
PPP1R13B-like protein

PPP1R13L SNPs

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  1. RS6966 (PPP1R13L) ??

Top Gene-Substance Interactions

PPP1R13L Interacts with These Diseases

Disease Score

Substances That Increase PPP1R13L

Substances Interaction Organism Category

Substances That Decrease PPP1R13L

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • p53
  • NF-kappaB1

Tissue specificity:

Highly expressed in heart, placenta and prostate. Weakly expressed in brain, liver, skeletal muscle, testis and peripheral blood leukocyte.

Caution:

An alternative product iASPP(RAI) has been described (PubMed:15489900, PubMed:10336463). However, it is not detected in vivo and is most probably a cloning artifact (PubMed:15489900).

Molecular Function:

  • Cadherin Binding Involved In Cell-Cell Adhesion
  • Identical Protein Binding
  • Transcription Corepressor Activity
  • Transcription Factor Binding

Biological Processes:

  • Apoptotic Process
  • Cardiac Muscle Contraction
  • Cardiac Right Ventricle Morphogenesis
  • Embryonic Camera-Type Eye Development
  • Hair Cycle
  • Multicellular Organismal Homeostasis
  • Multicellular Organism Growth
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Positive Regulation Of Cell Differentiation
  • Post-Embryonic Development
  • Regulation Of Signal Transduction By P53 Class Mediator
  • Transcription, Dna-Templated
  • Ventricular Cardiac Muscle Tissue Development
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AV260376| I79_012654| IASPP| inhibitor of apoptosis stimulating protein of p53| inhibitor of ASPP protein| M91_05725| MDA_GLEAN10005787| NFkB interacting protein 1| Nkip1| PAL_GLEAN10004023| PPP1R13B-like protein| protein iASPP| protein phosphatase 1, regulatory (inhibitor) subunit 13 like| protein phosphatase 1, regulatory subunit 13 like| RAI| RAI4| RelA-associated inhibitor| relA-associated inhibitor-like| retinoic acid induced 4| TREES_T100011439| UY3_16733| wa3| Y1Q_003294| ppp1r13l

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