The Function of PPP1R13L
Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis.
Protein names
Recommended name:
RelA-associated inhibitorAlternative name(s):
Inhibitor of ASPP proteinProtein iASPP
NFkB-interacting protein 1
PPP1R13B-like protein
- RS6966 (PPP1R13L) ??
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Top Gene-Substance Interactions
PPP1R13L Interacts with These Diseases
| Disease | Score |
Substances That Increase PPP1R13L
| Substances | Interaction | Organism | Category |
Substances That Decrease PPP1R13L
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in heart, placenta and prostate. Weakly expressed in brain, liver, skeletal muscle, testis and peripheral blood leukocyte.
Caution:
An alternative product iASPP(RAI) has been described (PubMed:15489900, PubMed:10336463). However, it is not detected in vivo and is most probably a cloning artifact (PubMed:15489900).
Molecular Function:
- Cadherin Binding Involved In Cell-Cell Adhesion
- Identical Protein Binding
- Transcription Corepressor Activity
- Transcription Factor Binding
Biological Processes:
- Apoptotic Process
- Cardiac Muscle Contraction
- Cardiac Right Ventricle Morphogenesis
- Embryonic Camera-Type Eye Development
- Hair Cycle
- Multicellular Organismal Homeostasis
- Multicellular Organism Growth
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Cell Differentiation
- Post-Embryonic Development
- Regulation Of Signal Transduction By P53 Class Mediator
- Transcription, Dna-Templated
- Ventricular Cardiac Muscle Tissue Development