The Function of PPM1E
Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42. Dephosphorylates PRKAA2.
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Protein names
Recommended name:
Protein phosphatase 1EAlternative name(s):
Ca(2+CaMKP-N
CaMKP-nucleus
CaMKN
Partner of PIX 1
Partner of PIX-alpha
Partner of PIXA
- RS9303401 (PPM1E) ??
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Top Gene-Substance Interactions
Substances That Increase PPM1E
| Substances | Interaction | Organism | Category |
Substances That Decrease PPM1E
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Cofactor:
Binds 2 magnesium or manganese ions per subunit.
Molecular Function:
- Protein Serine/Threonine Phosphatase Activity
- Ctd Phosphatase Activity
- Manganese Ion Binding
- Metal Ion Binding
Biological Processes:
- Negative Regulation Of Protein Kinase Activity
- Protein Dephosphorylation
- Peptidyl-Threonine Dephosphorylation
- Positive Regulation Of Stress Fiber Assembly