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  3. PPM1E

PPM1E (Protein phosphatase, Mg2+/Mn2+ dependent 1E)

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The Function of PPM1E

Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42. Dephosphorylates PRKAA2.

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Protein names

Recommended name:

Protein phosphatase 1E

Alternative name(s):

Ca(2+
CaMKP-N
CaMKP-nucleus
CaMKN
Partner of PIX 1
Partner of PIX-alpha
Partner of PIXA

PPM1E SNPs

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  1. RS9303401 (PPM1E) ??

Top Gene-Substance Interactions

Substances That Increase PPM1E

Substances Interaction Organism Category

Substances That Decrease PPM1E

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

Cofactor:

Binds 2 magnesium or manganese ions per subunit.

Molecular Function:

  • Ctd Phosphatase Activity
  • Manganese Ion Binding
  • Metal Ion Binding
  • Protein Serine/Threonine Phosphatase Activity

Biological Processes:

  • Protein Dephosphorylation
  • Negative Regulation Of Protein Kinase Activity
  • Peptidyl-Threonine Dephosphorylation
  • Positive Regulation Of Stress Fiber Assembly
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_11726| AS27_13501| AS28_07122| ca(2+)/calmodulin-dependent protein kinase phosphatase N| Ca/calmodulin-dependent protein kinase phosphatase-N| calmodulin-dependent protein kinase phosphatase N| caMKN| camkp-n| caMKP-nucleus| CB1_000552035| GW7_13088| H920_06407| M91_18588| M959_13493| MDA_GLEAN10012134| N300_11165| N301_15387| N302_07711| N303_12458| N305_15177| N306_12098| N307_07299| N308_07032| N310_07481| N311_04712| N312_11646| N320_01602| N321_07771| N322_01500| N324_01546| N325_10083| N326_12774| N327_07198| N328_06152| N329_09563| N330_08301| N331_03921| N332_13161| N333_00690| N334_08030| N335_04790| N336_11828| N339_12618| N340_08042| N341_00789| nuclear calmodulin-dependent protein kinase phosphatase| PAL_GLEAN10019793| PANDA_012503| partner of PIX 1| partner of PIXA| partner of PIX-alpha| POPX1| PP2CH| Protein phosphatase 1E| protein phosphatase 1E (PP2C domain containing)| protein phosphatase, Mg2+/Mn2+ dependent, 1E| TREES_T100015102| UY3_05021| Y1Q_003939| Y956_06550| Z169_00841| ppm1e

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