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  3. PPM1B

PPM1B (Protein phosphatase, Mg2+/Mn2+ dependent 1B)

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The Function of PPM1B

Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.

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Protein names

Recommended name:

Protein phosphatase 1B

Alternative name(s):

Protein phosphatase 2C isoform beta
PP2C-beta

PPM1B SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS4953076 (PPM1B) ??

Top Gene-Substance Interactions

PPM1B Interacts with These Diseases

Disease Score

Substances That Increase PPM1B

Substances Interaction Organism Category

Substances That Decrease PPM1B

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • NF-kappaB1

Tissue specificity:

Highly expressed in heart and skeletal muscle.

Gene Pathways:

  • Immune System
  • MAPK signaling pathway

Cofactor:

Binds 2 magnesium or manganese ions per subunit.

Molecular Function:

  • Magnesium Ion Binding
  • Manganese Ion Binding
  • Protein Serine/Threonine Phosphatase Activity

Biological Processes:

  • Negative Regulation Of Defense Response To Virus
  • Negative Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
  • Negative Regulation Of Interferon-Beta Production
  • Negative Regulation Of Nf-Kappab Import Into Nucleus
  • N-Terminal Protein Myristoylation
  • Peptidyl-Threonine Dephosphorylation
  • Protein Dephosphorylation
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_06192| AS27_01429| AS28_15060| CB1_000929004| EGK_05287| EH28_10517| GW7_00109| M959_02171| N300_11396| N301_04453| N302_06857| N303_07572| N305_00199| N306_11657| N307_14456| N308_10613| N309_14584| N310_01835| N312_13648| N320_01684| N321_04004| N322_03686| N325_00482| N326_09588| N327_01789| N328_11439| N329_07726| N330_12774| N331_11990| N332_03876| N333_09727| N334_10258| N335_14275| N336_05592| N339_01461| N340_05271| N341_13019| PAL_GLEAN10021295| PANDA_000196| Pp2c2| PP2CB| PP2C-beta| PP2CBETA| PP2C-beta-X| ppc2betax| ppm1b protein| Protein phosphatase 1B| protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform| protein phosphatase 1B , magnesium-dependent, beta isoform| protein phosphatase 1B magnesium-dependent beta isoform| protein phosphatase 1B, magnesium dependent, beta isoform| protein phosphatase 2C isoform beta| protein phosphatase 2C-like protein| protein phosphatase, Mg2+/Mn2+ dependent, 1B| Protein phosphatase type 1B (formely 2C) Mg-dependent beta isoform| Protein phosphatase type 1B (formely 2C), Mg-dependent, beta isoform| Ser/Thr protein phosphatase type 2C beta 2 isoform| TREES_T100004538| UY3_00158| XELAEV_18028742mg| Y1Q_027098| Y956_07769| Z169_03124| ppm1b

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