The Function of PPM1B
Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.
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Protein names
Recommended name:
Protein phosphatase 1BAlternative name(s):
Protein phosphatase 2C isoform betaPP2C-beta
- RS4953076 (PPM1B) ??
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Top Gene-Substance Interactions
PPM1B Interacts with These Diseases
| Disease | Score |
Substances That Increase PPM1B
| Substances | Interaction | Organism | Category |
Substances That Decrease PPM1B
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in heart and skeletal muscle.
Gene Pathways:
Cofactor:
Binds 2 magnesium or manganese ions per subunit.
Molecular Function:
Biological Processes:
- Protein Dephosphorylation
- N-Terminal Protein Myristoylation
- Negative Regulation Of Interferon-Beta Production
- Peptidyl-Threonine Dephosphorylation
- Negative Regulation Of Nf-Kappab Import Into Nucleus
- Negative Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
- Negative Regulation Of Defense Response To Virus