The Function of PPIL2
May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins (By similarity). May also function as a chaperone, playing a role in transport to the cell membrane of BSG for instance (PubMed:15946952). May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation (PubMed:11435423).
Protein names
Recommended name:
Peptidyl-prolyl cis-trans isomerase-like 2Short name:
CYC4Alternative name(s):
PPIaseCyclophilin-60
Cyclophilin-like protein Cyp-60
Cyp60
hCyP-60
Rotamase PPIL2
- RS79384503 (PPIL2) ??
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Top Gene-Substance Interactions
Substances That Increase PPIL2
| Substances | Interaction | Organism | Category |
Substances That Decrease PPIL2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highest expression in thymus, pancreas and testis. Also detected in heart, placenta, lung, liver, skeletal muscle, kidney, spleen, prostate, ovary, small intestine and colon. Poorly detected in brain and leukocytes. Strong protein expression in lymph node (cortical, paracortical and medullar regions), thyroid (follicular epithelial cells), testis (developing spermatozoa), stomach (cells lining the gastric pit), pancreas, kidney (proximal and distal-tubule cells and collecting duct cells but not in glomeruli), endometrium and colon (goblet cells). Moderate protein expression in spleen, prostate (epithelium and squamous cell carcinomas), placenta and adrenal gland. Weak protein expression in liver, heart, breast, ovary, and lung. No protein expression in brain and bladder. High protein expression in most lymphomas and melanomas.
Molecular Function:
- Ligase Activity
- Peptidyl-Prolyl Cis-Trans Isomerase Activity
- Ubiquitin Protein Ligase Activity
- Ubiquitin-Ubiquitin Ligase Activity
Biological Processes:
- Leukocyte Migration
- Protein Folding
- Protein Localization To Plasma Membrane
- Protein Polyubiquitination