The Function of PPIF
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.
Protein names
Recommended name:
Peptidyl-prolyl cis-trans isomerase F, mitochondrialAlternative name(s):
PPIase FCyclophilin D
CyP-D
CypD
Cyclophilin F
Mitochondrial cyclophilin
CyP-M
Rotamase F
- RS1923367 (PPIF) ??
- RS2145998 (PPIF) ??
- RS941873 (PPIF) ??
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Top Gene-Substance Interactions
PPIF Interacts with These Diseases
| Disease | Score |
Substances That Increase PPIF
| Substances | Interaction | Organism | Category |
Substances That Decrease PPIF
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Enzyme Regulation:
Binds cyclosporin A (CsA). Is displaced by CsA from the mPTP leading to a lower open probability of the mPTP.
Molecular Function:
Biological Processes:
- Apoptotic Mitochondrial Changes
- Cellular Response To Arsenic-Containing Substance
- Cellular Response To Calcium Ion
- Cellular Response To Hydrogen Peroxide
- Necroptotic Process
- Negative Regulation Of Apoptotic Process
- Negative Regulation Of Atpase Activity
- Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
- Negative Regulation Of Oxidative Phosphorylation
- Negative Regulation Of Oxidative Phosphorylation Uncoupler Activity
- Negative Regulation Of Release Of Cytochrome C From Mitochondria
- Positive Regulation Of Release Of Cytochrome C From Mitochondria
- Protein Folding
- Regulation Of Mitochondrial Membrane Permeability
- Regulation Of Mitochondrial Membrane Permeability Involved In Programmed Necrotic Cell Death
- Regulation Of Necrotic Cell Death
- Regulation Of Proton-Transporting Atpase Activity, Rotational Mechanism
- Response To Ischemia