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  3. PPIF

PPIF (Peptidylprolyl isomerase F)

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The Function of PPIF

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.

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Protein names

Recommended name:

Peptidyl-prolyl cis-trans isomerase F, mitochondrial

Alternative name(s):

PPIase F
Cyclophilin D
CyP-D
CypD
Cyclophilin F
Mitochondrial cyclophilin
CyP-M
Rotamase F

PPIF SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1923367 (PPIF) ??
  2. RS2145998 (PPIF) ??
  3. RS941873 (PPIF) ??

Top Gene-Substance Interactions

PPIF Interacts with These Diseases

Disease Score

Substances That Increase PPIF

Substances Interaction Organism Category

Substances That Decrease PPIF

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • PPAR-gamma1
  • PPAR-gamma2
  • NF-kappaB1
  • C/EBPalpha
  • YY1
  • FOXC1
  • c-Myb
  • NF-kappaB2
  • RelA

Gene Pathways:

  • Toxoplasmosis

Enzyme Regulation:

Binds cyclosporin A (CsA). Is displaced by CsA from the mPTP leading to a lower open probability of the mPTP.

Molecular Function:

  • Cyclosporin A Binding
  • Peptidyl-Prolyl Cis-Trans Isomerase Activity

Biological Processes:

  • Apoptotic Mitochondrial Changes
  • Cellular Response To Arsenic-Containing Substance
  • Cellular Response To Calcium Ion
  • Cellular Response To Hydrogen Peroxide
  • Necroptotic Process
  • Negative Regulation Of Apoptotic Process
  • Negative Regulation Of Atpase Activity
  • Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
  • Negative Regulation Of Oxidative Phosphorylation
  • Negative Regulation Of Oxidative Phosphorylation Uncoupler Activity
  • Negative Regulation Of Release Of Cytochrome C From Mitochondria
  • Positive Regulation Of Release Of Cytochrome C From Mitochondria
  • Protein Folding
  • Regulation Of Mitochondrial Membrane Permeability
  • Regulation Of Mitochondrial Membrane Permeability Involved In Programmed Necrotic Cell Death
  • Regulation Of Necrotic Cell Death
  • Regulation Of Proton-Transporting Atpase Activity, Rotational Mechanism
  • Response To Ischemia

Drug Bank:

  • L-Proline
  • Cyclosporine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| PPIase| cyclophilin| cyclophilin D| AS27_09562| AS28_06558| CB1_000463022| cyclophilin 3| cyclophilin F| CYP3| CypD| Cyp-D| cypf| CyP-F| CyP-M| GW7_09017| H920_02447| M91_00365| M959_04716| MDA_GLEAN10013890| mitochondrial cyclophilin| mitochondrial Cyclophilin D| N300_15350| N301_14087| N302_07424| N303_14032| N305_09383| N306_13708| N307_00219| N308_15409| N309_06550| N310_02155| N311_04890| N312_01534| N333_01775| N335_05521| N341_10836| PAL_GLEAN10020455| PANDA_011431| peptidyl-prolyl cis-trans isomerase F, mitochondrial| Peptidyl-prolyl cis-trans isomerase, mitochondrial| peptidylprolyl isomerase F (cyclophilin F)| PPIase F| rotamase F| TREES_T100001842| Y1Q_009377| Y956_09317| Z169_12704| ppif

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