Summary of PPARGC1A
The PPARGC1A gene encodes a protein called PPARG coactivator 1 alpha, or PGC-1α [R].
PGC-1α regulates the expression of genes that help produce energy in the cell. Along with UCP3 , PPARGC1A helps your body stay warm by converting energy into heat [R].
PGC-1α increases PPARG and thyroid hormone levels. It also affects how energy metabolism changes over the course of a 24 hour cycle (following a circadian rhythm) [R, R].
Variants in PPARGC1A have been linked to [R, R]:
- Body mass index
- High blood sugar
Protein names
Recommended name:
Peroxisome proliferator-activated receptor gamma coactivator 1-alphaAlternative name(s):
PGC-1-alphaPPAR-gamma coactivator 1-alpha
PPARGC-1-alpha
Ligand effect modulator 6
- RS11730701 (PPARGC1A) ??
- RS16875528 (PPARGC1A) ??
- RS17650401 (PPARGC1A) ??
- RS188794202 (PPARGC1A) ??
- RS2970848 (PPARGC1A) ??
- RS2970869 (PPARGC1A) ??
- RS3755863 (PPARGC1A) ??
- RS3774923 (PPARGC1A) ??
- RS41359445 (PPARGC1A) ??
- RS7656250 (PPARGC1A) ??
- RS7665116 (PPARGC1A) ??
- RS7698250 (PPARGC1A) ??
- RS8192678 (PPARGC1A) ??
- RS9930506 (PPARGC1A) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
PPARGC1A Interacts with These Diseases
| Disease | Score |
Fixes
How to Increase PGC-1a
Lifestyle
Fixes Advanced
How to Increase PGC-1a
Nutrients:
Supplements:
- PQQ
- Hydroxytyrosol (R)
- Resveratrol (R)
- Nicotinamide Riboside (R)
- EGCG/Tea (R)
- Red yeast rice (R)
- Gotu Kola (R)
- Grape Seed Extract (R)
- R-Lipoic Acid (R)
- Epimedium (R) and Icariin (R)
- Carnitine (R)
- Rhodiola/Salidrosides (R)
- Aspirin (R)
- Quercetin (R)
- Forskolin/Cyclic AMP (R)
Hormones/Neurotransmitters:
Pathways
I’ve already discussed some common pathways to activate PGC-1a. This means that if you activate these, it will help activate PGC-1a.
Substances That Increase PPARGC1A
| Substances | Interaction | Organism | Category |
Substances That Decrease PPARGC1A
| Substances | Interaction | Organism | Category |
Advanced Summary
Read: About PGC-1alpha and Natural Ways to Increase It.
PGC-1a is one of the most important factors in controlling mitochondrial health. PGC-1 makes new mitochondria and improves its function. PGC-1 increases energy metabolism and weight loss. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity .
PGC-1a protects against neurodegenerative diseases. PGC-1 decreases inflammation (R) and insulin resistance. PGC-1a increases fatty acid burning by increasing the carnitine genes (CPT1A (R)).
PGC-1a increase Nrf2 (R), which is important for detoxing. PGC-1a increases PXR (R), which plays an integral role in drug/toxin metabolism by regulating the expression of drug metabolizing enzymes and transporters.
PGC-1 alpha stimulates the expression of clock genes, notably Bmal1 and Rev-erb alpha (R). Mice lacking PGC-1 alpha show abnormal circadian rhythms, body temperature, and metabolic rate (R).
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Heart, skeletal muscle, liver and kidney. Expressed at lower levels in brain and pancreas and at very low levels in the intestine and white adipose tissue. In skeletal muscle, levels were lower in obese than in lean subjects and fasting induced a 2-fold increase in levels in the skeletal muscle in obese subjects.
Gene Pathways:
Induction:
Transcription is repressed by ZNF746 which binds to 'insulin response sequences' its promoter.
Molecular Function:
- Nucleotide Binding
- Rna Polymerase Ii Transcription Cofactor Activity
- Dna Binding
- Transcription Coactivator Activity
- Rna Binding
- Transcription Factor Binding
- Ligand-Dependent Nuclear Receptor Binding
- Ligand-Dependent Nuclear Receptor Transcription Coactivator Activity
- Chromatin Dna Binding
- Ubiquitin Protein Ligase Binding
- Sequence-Specific Dna Binding
- Androgen Receptor Binding
- Promoter-Specific Chromatin Binding
Biological Processes:
- Response To Reactive Oxygen Species
- Mitophagy
- Temperature Homeostasis
- Cellular Glucose Homeostasis
- Negative Regulation Of Protein Phosphorylation
- Response To Dietary Excess
- Response To Ischemia
- Galactose Metabolic Process
- Gluconeogenesis
- Regulation Of Transcription, Dna-Templated
- Transcription Initiation From Rna Polymerase Ii Promoter
- Mrna Processing
- Protein Complex Assembly
- Mitochondrion Organization
- Aging
- Digestion
- Circadian Rhythm
- Androgen Metabolic Process
- Rna Splicing
- Response To Cold
- Positive Regulation Of Mitochondrion Organization
- Skeletal Muscle Atrophy
- Response To Muscle Activity
- Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation
- Negative Regulation Of Smooth Muscle Cell Migration
- Fatty Acid Oxidation
- Cerebellum Development
- Respiratory Electron Transport Chain
- Androgen Receptor Signaling Pathway
- Forebrain Development
- Circadian Regulation Of Gene Expression
- Cellular Response To Oxidative Stress
- Positive Regulation Of Histone Acetylation
- Cellular Response To Potassium Ion
- Response To Starvation
- Regulation Of Circadian Rhythm
- Response To Leucine
- Negative Regulation Of Neuron Apoptotic Process
- Cellular Respiration
- Positive Regulation Of Gluconeogenesis
- Negative Regulation Of Glycolytic Process
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Fatty Acid Oxidation
- Positive Regulation Of Smooth Muscle Cell Proliferation
- Negative Regulation Of Smooth Muscle Cell Proliferation
- Protein Stabilization
- Brown Fat Cell Differentiation
- Positive Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
- Flavone Metabolic Process
- Adipose Tissue Development
- Cellular Response To Lipopolysaccharide
- Cellular Response To Nitrite
- Cellular Response To Caffeine
- Cellular Response To Fructose Stimulus
- Cellular Response To Glucose Stimulus
- Cellular Response To Interleukin-6
- Cellular Response To Tumor Necrosis Factor
- Cellular Response To Follicle-Stimulating Hormone Stimulus
- Cellular Response To Estradiol Stimulus
- Cellular Response To Hypoxia
- Cellular Response To Transforming Growth Factor Beta Stimulus
- Response To Epinephrine
- Response To Norepinephrine
- Negative Regulation Of Mitochondrial Fission
- Cellular Response To Thyroid Hormone Stimulus
- Negative Regulation Of Neuron Death
- Response To Metformin
- Positive Regulation Of Cellular Respiration
- Positive Regulation Of Mitochondrial Dna Metabolic Process
- Positive Regulation Of Muscle Tissue Development
- Positive Regulation Of Glomerular Visceral Epithelial Cell Apoptotic Process
- Cellular Response To Ionomycin
- Cellular Response To Resveratrol
- Response To Methionine
- Adaptive Thermogenesis
- Positive Regulation Of Progesterone Biosynthetic Process
- Negative Regulation Of Receptor Activity
- Regulation Of N-Methyl-D-Aspartate Selective Glutamate Receptor Activity
- Positive Regulation Of Energy Homeostasis
- Positive Regulation Of Atp Biosynthetic Process