POMC (proopiomelanocortin) makes a protein that is cut into peptides that have different functions in the body (R). 

Adrenocorticotropic hormone (ACTH) is produced from the POMC protein and it helps maintain blood sugar levels, protects the body from stress, and stops inflammation (R).

Other peptides formed from POMC include: β-MSH peptide, which plays a role in weight regulation; α-MSH peptide, which helps maintain the correct energy balance; γ-MSH, which is involved in regulating the amount of sodium in the body and controlling blood pressure; and β-endorphin, which stimulates signaling for pain relief (R).

     proopiomelanocortin deficiency Several mutations in the POMC gene have been found in people with proopiomelanocortin (POMC) deficiency. These gene mutations lead to production of an abnormally short version of the POMC protein or no protein at all. As a result, there is an absence of the peptides made from POMC, including ACTH, α-MSH, β-MSH, β-endorphin, and sometimes γ-MSH. Loss of these peptides prevents signaling through their receptor proteins and disrupts certain functions in the body. Without ACTH, there is a reduction in cortisol production, which leads to low blood sugar (hypoglycemia) and other problems in affected individuals. Decreased α-MSH in the skin reduces pigment production in melanocytes, which results in the red hair and pale skin often seen in people with POMC deficiency. Loss of signaling in the brain stimulated by α-MSH and β-MSH dysregulates the body's energy balance, leading to overeating and severe obesity . Shortage of γ-MSH or β-endorphin does not seem to cause health problems in people with this condition.

     The POMC gene provides instructions for making a protein called proopiomelanocortin (POMC), which is cut (cleaved) into smaller pieces called peptides that have different functions in the body. The peptides attach (bind) to one of several proteins in different regions of the body, and this binding triggers signaling pathways that control many important functions. One peptide produced from the POMC protein is called adrenocorticotropic hormone (ACTH). ACTH binds to melanocortin 2 receptor (MC2R), stimulating the release of a hormone called cortisol . This hormone helps maintain blood sugar levels, protects the body from stress, and stops (suppresses) inflammation. Three similar peptides called alpha-, beta-, and gamma-melanocyte stimulating hormones (α-, β-, and γ-MSH) are also cut from the POMC protein. The primary role of α-MSH is in the pigment-producing cells of the skin and hair (melanocytes), where it binds to melanocortin 1 receptor (MC1R). This attachment stimulates the production and release of a pigment called melanin, which is the substance that gives skin and hair their color. The β-MSH peptide plays a role in weight regulation by binding to melanocortin 4 receptor (MC4R). Signaling through this receptor in the brain helps maintain the balance between energy from food taken into the body and energy spent by the body. The correct balance is important to control eating and weight . The α-MSH peptide can also bind to MC4R and help maintain the correct energy balance. Studies show that γ-MSH binds to melanocortin 3 receptor (MC3R). Signaling stimulated by this interaction appears to be involved in regulating the amount of sodium in the body and controlling blood pressure, although the mechanism is unclear. Another peptide produced from POMC is β-endorphin. Attachment of β-endorphin to proteins in the brain called opioid receptors stimulates signaling for pain relief.

The following transcription factors affect gene expression:

• p53
• CREB
• AP-1
• Max
• c-Jun
• deltaCREB
• STAT3
• NF-kappaB1
• c-Myc

Tissue specificity:

ACTH and MSH are produced by the pituitary gland.

Molecular Function:

• G-Protein Coupled Receptor Binding
• Hormone Activity
• Neuropeptide Hormone Activity
• Receptor Binding
• Type 1 Melanocortin Receptor Binding
• Type 3 Melanocortin Receptor Binding
• Type 4 Melanocortin Receptor Binding

Biological Processes:

• Cell-Cell Signaling
• Cellular Pigmentation
• Generation Of Precursor Metabolites And Energy
• Glucose Homeostasis
• Negative Regulation Of Tumor Necrosis Factor Production
• Neuropeptide Signaling Pathway
• Peptide Hormone Processing
• Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
• Regulation Of Appetite
• Regulation Of Blood Pressure
• Regulation Of Corticosterone Secretion
• Regulation Of Glycogen Metabolic Process
• Signal Transduction

Drug Bank:

• Loperamide