• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. POLR3K

POLR3K (RNA polymerase III subunit K)

Loading...

The Function of POLR3K

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.

0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

DNA-directed RNA polymerase III subunit RPC10

Short name:

RPC11

Alternative name(s):

RNA polymerase III subunit C10
DNA-directed RNA polymerase III subunit K
RNA polymerase III 12.5 kDa subunit
RPC12.5
RNA polymerase III subunit C11
HsC11p
hRPC11

Top Gene-Substance Interactions

Substances That Increase POLR3K

Substances Interaction Organism Category

Substances That Decrease POLR3K

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • STAT3
  • c-Myc
  • STAT1
  • STAT1beta
  • STAT1alpha
  • SREBP-1a
  • SREBP-1c
  • SREBP-1b
  • AREB6

Gene Pathways:

  • Metabolic pathways
  • Immune System
  • Gene Expression
  • Cytosolic DNA-sensing pathway
  • Purine metabolism
  • Pyrimidine metabolism
  • Transcription
  • RNA polymerase

Molecular Function:

  • Dna-Directed 5'-3' Rna Polymerase Activity
  • Nucleic Acid Binding
  • Zinc Ion Binding

Biological Processes:

  • Defense Response To Virus
  • Innate Immune Response
  • Positive Regulation Of Type I Interferon Production
  • Termination Of Rna Polymerase Iii Transcription
  • Transcription From Rna Polymerase Iii Promoter
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| C11| 12.3kDa| C11-RNP3| Ci-RP-2| D623_10017155| DNA directed RNA polymerase III polypeptide K| DNA-directed RNA polymerase III subunit K| DNA-directed RNA polymerase III subunit RPC10| DNA-directed RNA polymerases III 12.5 kDa polypeptide| EH28_07917| estrous-specific protein, 250 kDa| GW7_13007| H920_03826| My010| N303_10785| N332_07506| PAL_GLEAN10011819| PANDA_008903| polymerase III polypeptide K, 12.3 kDa| polymerase (RNA) III (DNA directed) polypeptide K| polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa| polymerase (RNA) III subunit K| RNA polymerase III 12.5 kDa subunit| RNA polymerase III subunit C10| RNA polymerase III subunit C11| RNA polymerase III subunit CII| RPC10| RPC11| RPC12.5| TREES_T100011775| Y1Q_028689| polr3k

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved