The Function of POLR3K
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.
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Protein names
Recommended name:
DNA-directed RNA polymerase III subunit RPC10Short name:
RPC11Alternative name(s):
RNA polymerase III subunit C10DNA-directed RNA polymerase III subunit K
RNA polymerase III 12.5 kDa subunit
RPC12.5
RNA polymerase III subunit C11
HsC11p
hRPC11
Top Gene-Substance Interactions
Substances That Increase POLR3K
| Substances | Interaction | Organism | Category |
Substances That Decrease POLR3K
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
Biological Processes:
- Transcription From Rna Polymerase Iii Promoter
- Positive Regulation Of Type I Interferon Production
- Innate Immune Response
- Defense Response To Virus
- Termination Of Rna Polymerase Iii Transcription