The Function of POLD1
Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex.
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Protein names
Recommended name:
DNA polymerase delta catalytic subunitAlternative name(s):
DNA polymerase subunit delta p125- RS2230245 (POLD1) ??
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Top Gene-Substance Interactions
POLD1 Interacts with These Diseases
| Disease | Score |
Substances That Increase POLD1
| Substances | Interaction | Organism | Category |
Substances That Decrease POLD1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed across a panel of tissues, with high levels of expression in heart and lung.
Gene Pathways:
Cofactor:
Binds 1 [4Fe-4S] cluster.
Molecular Function:
- 3'-5'-Exodeoxyribonuclease Activity
- 4 Iron, 4 Sulfur Cluster Binding
- Chromatin Binding
- Damaged Dna Binding
- Dna Binding
- Dna-Directed Dna Polymerase Activity
- Metal Ion Binding
- Nucleotide Binding
Biological Processes:
- Base-Excision Repair, Gap-Filling
- Cellular Response To Uv
- Dna Damage Response, Detection Of Dna Damage
- Dna Repair
- Dna Replication
- Dna Replication Proofreading
- Dna Strand Elongation Involved In Dna Replication
- Dna Synthesis Involved In Dna Repair
- Fatty Acid Homeostasis
- Mismatch Repair
- Nucleotide-Excision Repair, Dna Gap Filling
- Nucleotide-Excision Repair, Dna Incision
- Nucleotide-Excision Repair, Dna Incision, 5'-To Lesion
- Response To Uv
- Telomere Maintenance
- Telomere Maintenance Via Recombination
- Transcription-Coupled Nucleotide-Excision Repair
- Translesion Synthesis