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  3. POLD1

POLD1 (DNA polymerase delta 1, catalytic subunit)

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The Function of POLD1

Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex.

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Protein names

Recommended name:

DNA polymerase delta catalytic subunit

Alternative name(s):

DNA polymerase subunit delta p125

POLD1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2230245 (POLD1) ??

Top Gene-Substance Interactions

POLD1 Interacts with These Diseases

Disease Score

Substances That Increase POLD1

Substances Interaction Organism Category

Substances That Decrease POLD1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • NF-kappaB1
  • E2F-1
  • Roaz

Tissue specificity:

Expressed across a panel of tissues, with high levels of expression in heart and lung.

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Base excision repair
  • DNA Repair
  • DNA replication
  • DNA Replication
  • Mismatch repair
  • Nucleotide excision repair
  • Purine metabolism
  • Pyrimidine metabolism

Cofactor:

Binds 1 [4Fe-4S] cluster.

Molecular Function:

  • 3'-5'-Exodeoxyribonuclease Activity
  • 4 Iron, 4 Sulfur Cluster Binding
  • Chromatin Binding
  • Damaged Dna Binding
  • Dna Binding
  • Dna-Directed Dna Polymerase Activity
  • Metal Ion Binding
  • Nucleotide Binding

Biological Processes:

  • Base-Excision Repair, Gap-Filling
  • Cellular Response To Uv
  • Dna Damage Response, Detection Of Dna Damage
  • Dna Repair
  • Dna Replication
  • Dna Replication Proofreading
  • Dna Strand Elongation Involved In Dna Replication
  • Dna Synthesis Involved In Dna Repair
  • Fatty Acid Homeostasis
  • Mismatch Repair
  • Nucleotide-Excision Repair, Dna Gap Filling
  • Nucleotide-Excision Repair, Dna Incision
  • Nucleotide-Excision Repair, Dna Incision, 5'-To Lesion
  • Response To Uv
  • Telomere Maintenance
  • Telomere Maintenance Via Recombination
  • Transcription-Coupled Nucleotide-Excision Repair
  • Translesion Synthesis
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| CDC2| 125kDa| CDC2 homolog| CRCS10| DAN polymerase delta 1, catalytic subunit| DNA-directed DNA polymerase delta 1| DNA polymerase delta 1, catalytic domain| DNA polymerase delta1 catalytic subunit| DNA polymerase delta catalytic subunit| DNA polymerase delta, catalytic subunit| DNA polymerase subunit delta p125| fla| flat head| I79_019313| MDA_GLEAN10005288| MDPL| PAL_GLEAN10004508| pold| polymerase , delta 1, catalytic subunit 125kDa| polymerase (DNA) delta 1, catalytic subunit| polymerase (DNA directed), delta 1, catalytic subunit| polymerase (DNA directed), delta 1, catalytic subunit 125kDa| TREES_T100006319| pold1

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