• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. POLB

POLB (DNA polymerase beta)

Loading...

The Function of POLB

Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.

0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

DNA polymerase beta

POLB SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2953983 (POLB) ??
  2. RS3136739 (POLB) ??
  3. RS3136797 (POLB) ??

Top Gene-Substance Interactions

POLB Interacts with These Diseases

Disease Score

Substances That Increase POLB

Substances Interaction Organism Category

Substances That Decrease POLB

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p300

Gene Pathways:

  • Base excision repair
  • DNA Repair

Cofactor:

Binds 2 magnesium ions per subunit.

Molecular Function:

  • Damaged Dna Binding
  • Dna-(Apurinic Or Apyrimidinic Site) Lyase Activity
  • Dna-Directed Dna Polymerase Activity
  • Enzyme Binding
  • Lyase Activity
  • Metal Ion Binding
  • Microtubule Binding

Biological Processes:

  • Aging
  • Base-Excision Repair
  • Base-Excision Repair, Base-Free Sugar-Phosphate Removal
  • Base-Excision Repair, Dna Ligation
  • Base-Excision Repair, Gap-Filling
  • Cellular Response To Dna Damage Stimulus
  • Dna-Dependent Dna Replication
  • Dna Repair
  • Homeostasis Of Number Of Cells
  • Immunoglobulin Heavy Chain V-D-J Recombination
  • Inflammatory Response
  • Intrinsic Apoptotic Signaling Pathway In Response To Dna Damage
  • Lymph Node Development
  • Neuron Apoptotic Process
  • Pyrimidine Dimer Repair
  • Response To Ethanol
  • Response To Gamma Radiation
  • Response To Hyperoxia
  • Salivary Gland Morphogenesis
  • Somatic Hypermutation Of Immunoglobulin Genes
  • Spleen Development

Drug Bank:

  • Cytarabine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| DNA damage-regulated autophagy modulator protein 1| A306_10682| AS27_08388| AS28_12431| D623_10030529| DNA-directed DNA polymerase beta| DNA pol beta| DNA polymerase beta subunit| EGK_18891| GW7_08532| H920_02162| M959_07339| MDA_GLEAN10024889| N300_03110| N301_08847| N302_03469| N303_05455| N305_12492| N306_11668| N307_07597| N308_00490| N309_04137| N310_12250| N311_09948| N312_06381| N321_08961| N322_10814| N324_10665| N325_00191| N326_05027| N327_05639| N329_10108| N331_01489| N332_07006| N333_09724| N335_06996| N336_07224| N340_07714| N341_10627| PAL_GLEAN10021536| PANDA_006859| Pol beta| polymerase-beta| polymerase (DNA) beta| polymerase (DNA directed), beta| TREES_T100019179| UY3_11153| Y1Q_016758| Y956_03220| Z169_11512| polb

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved