The Function of POLB
Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.
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Protein names
Recommended name:
DNA polymerase beta- RS2953983 (POLB) ??
- RS3136739 (POLB) ??
- RS3136797 (POLB) ??
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Top Gene-Substance Interactions
POLB Interacts with These Diseases
| Disease | Score |
Substances That Increase POLB
| Substances | Interaction | Organism | Category |
Substances That Decrease POLB
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Cofactor:
Binds 2 magnesium ions per subunit.
Molecular Function:
- Damaged Dna Binding
- Dna-Directed Dna Polymerase Activity
- Dna-(Apurinic Or Apyrimidinic Site) Lyase Activity
- Microtubule Binding
- Lyase Activity
- Enzyme Binding
- Metal Ion Binding
Biological Processes:
- Dna-Dependent Dna Replication
- Dna Repair
- Base-Excision Repair
- Base-Excision Repair, Base-Free Sugar-Phosphate Removal
- Base-Excision Repair, Gap-Filling
- Base-Excision Repair, Dna Ligation
- Pyrimidine Dimer Repair
- Inflammatory Response
- Cellular Response To Dna Damage Stimulus
- Salivary Gland Morphogenesis
- Aging
- Intrinsic Apoptotic Signaling Pathway In Response To Dna Damage
- Response To Gamma Radiation
- Somatic Hypermutation Of Immunoglobulin Genes
- Response To Ethanol
- Lymph Node Development
- Spleen Development
- Homeostasis Of Number Of Cells
- Neuron Apoptotic Process
- Response To Hyperoxia
- Immunoglobulin Heavy Chain V-D-J Recombination