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  3. PLTP

PLTP (Phospholipid transfer protein)

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The Function of PLTP

Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine. Essential for the transfer of excess surface lipids from triglyceride-rich lipoproteins to HDL, thereby facilitating the formation of smaller lipoprotein remnants, contributing to the formation of LDL, and assisting in the maturation of HDL particles. PLTP also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion. Two distinct forms of PLTP exist in plasma: an active form that can transfer PC from phospholipid vesicles to high-density lipoproteins (HDL), and an inactive form that lacks this capability.

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Protein names

Recommended name:

Phospholipid transfer protein

Alternative name(s):

Lipid transfer protein II

PLTP SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS3843763 (PLTP) ??
  2. RS4810479 (PLTP) ??
  3. RS59329875 (PLTP) ??
  4. RS6065904 (PLTP) ??
  5. RS6065906 (PLTP) ??
  6. RS6073958 (PLTP) ??

Top Gene-Substance Interactions

PLTP Interacts with These Diseases

Disease Score

Substances That Increase PLTP

Substances Interaction Organism Category

Substances That Decrease PLTP

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • E47

Tissue specificity:

Wide tissue distribution. Placenta > pancreas > lung > kidney > heart > liver > skeletal muscle > brain.

Gene Pathways:

  • PPAR signaling pathway

Molecular Function:

  • Lipid Binding

Biological Processes:

  • Flagellated Sperm Motility
  • High-Density Lipoprotein Particle Remodeling
  • Lipid Metabolic Process
  • Lipid Transport
  • Positive Regulation Of Cholesterol Efflux
  • Vitamin E Biosynthetic Process
  • Sperm Motility
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_08314| Anapl_17503| AS27_11039| Bpife| BPI fold containing family E| CB1_001010012| CTSA| H920_06185| HDLCQ9| lipid transfer protein II| lysosomal protective protein| M959_11047| N300_15606| N301_06131| N302_00259| N303_11917| N305_03128| N307_02888| N308_15799| N309_14155| N310_03774| N312_08709| N321_06446| N327_04134| N330_09491| N334_06404| N335_06093| N336_04998| OD107| PAL_GLEAN10024414| PANDA_018015| phospholipid transfer protein precursor-like protein| plasma phospholipid transfer protein| PLTP-like protein| TREES_T100020993| UY3_14621| Y956_07653| pltp

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