The Function of PLTP

Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine. Essential for the transfer of excess surface lipids from triglyceride-rich lipoproteins to HDL, thereby facilitating the formation of smaller lipoprotein remnants, contributing to the formation of LDL, and assisting in the maturation of HDL particles. PLTP also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion. Two distinct forms of PLTP exist in plasma: an active form that can transfer PC from phospholipid vesicles to high-density lipoproteins (HDL), and an inactive form that lacks this capability.

0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

Phospholipid transfer protein

Alternative name(s):

Lipid transfer protein II

Top Gene-Substance Interactions

PLTP Interacts with These Diseases

Substances That Increase PLTP

Substances That Decrease PLTP

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical