The Function of PLTP
Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine. Essential for the transfer of excess surface lipids from triglyceride-rich lipoproteins to HDL, thereby facilitating the formation of smaller lipoprotein remnants, contributing to the formation of LDL, and assisting in the maturation of HDL particles. PLTP also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion. Two distinct forms of PLTP exist in plasma: an active form that can transfer PC from phospholipid vesicles to high-density lipoproteins (HDL), and an inactive form that lacks this capability.
Protein names
Recommended name:
Phospholipid transfer proteinAlternative name(s):
Lipid transfer protein II- RS3843763 (PLTP) ??
- RS4810479 (PLTP) ??
- RS59329875 (PLTP) ??
- RS6065904 (PLTP) ??
- RS6065906 (PLTP) ??
- RS6073958 (PLTP) ??
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Top Gene-Substance Interactions
PLTP Interacts with These Diseases
Disease | Score |
Substances That Increase PLTP
Substances | Interaction | Organism | Category |
Substances That Decrease PLTP
Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Wide tissue distribution. Placenta > pancreas > lung > kidney > heart > liver > skeletal muscle > brain.
Gene Pathways:
Molecular Function:
Biological Processes:
- Flagellated Sperm Motility
- High-Density Lipoprotein Particle Remodeling
- Lipid Metabolic Process
- Lipid Transport
- Positive Regulation Of Cholesterol Efflux
- Vitamin E Biosynthetic Process
- Sperm Motility