• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. PLEKHA1

PLEKHA1 (Pleckstrin homology domain containing A1)

Loading...

The Function of PLEKHA1

Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane.

0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

Pleckstrin homology domain-containing family A member 1

Short name:

TAPP-1

Alternative name(s):

PH domain-containing family A member 1
Tandem PH domain-containing protein 1

PLEKHA1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10510110 (PLEKHA1) ??
  2. RS6585827 (PLEKHA1) ??

Top Gene-Substance Interactions

Substances That Increase PLEKHA1

Substances Interaction Organism Category

Substances That Decrease PLEKHA1

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Age-related macular degeneration 1

     From NCBI Gene: This gene encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is localized to the plasma membrane where it specifically binds phosphatidylinositol 3,4-bisphosphate. This protein may be involved in the formation of signaling complexes in the plasma membrane. Polymorphisms in this gene are associated with age-related macular degeneration. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5.[provided by RefSeq, Sep 2010] From UniProt: Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Evi-1
  • FAC1
  • Nkx3-1 v1
  • Nkx3-1

Tissue specificity:

Highly expressed in skeletal muscle, thymus, pancreas, placenta and lung. Detected at low levels in brain, heart, peripheral blood leukocytes, testis, ovary, spinal cord, thyroid, kidney, liver, small intestine and colon.

Molecular Function:

  • Lipid Binding
  • Pdz Domain Binding
  • Phosphatidylinositol-3,4-Bisphosphate Binding

Biological Processes:

  • Androgen Metabolic Process
  • B Cell Receptor Signaling Pathway
  • Cellular Response To Hydrogen Peroxide
  • Establishment Of Protein Localization
  • Estrogen Metabolic Process
  • Face Morphogenesis
  • Leydig Cell Differentiation
  • Luteinization
  • Multicellular Organism Growth
  • Negative Regulation Of Protein Kinase B Signaling
  • Palate Development
  • Phosphatidylinositol 3-Kinase Signaling
  • Platelet-Derived Growth Factor Receptor Signaling Pathway
  • Post-Embryonic Development
  • Ruffle Organization
  • Skeletal System Morphogenesis
  • Spermatogenesis
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Anapl_03490| AS27_02824| AS28_09718| CB1_098824009| GW7_05692| H920_08954| M959_05923| MDA_GLEAN10006690| N300_08972| N301_07102| N302_08698| N303_11652| N305_01464| N306_06639| N307_06005| N308_13564| N309_03176| N310_09803| N311_03283| N320_10883| N322_00710| N324_09095| N325_08168| N326_04629| N328_10764| N329_03523| N330_07668| N331_12019| N332_04482| N333_02051| N334_03648| N335_04249| N339_07308| N341_03442| PAL_GLEAN10003425| PANDA_013912| PH domain-containing family A member 1| PH domain-containing family A member 1-like protein| Pleckstrin homology domain-containing family A member 1| pleckstrin homology domain containing, family A (phosphoinositid| pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1| pleckstrin homology domain-containing protein family A member 1| Pleckstrin-like protein domain-containing family A member 1| pleckstrin-like proteiny domain-containing, family A member 1| Pleckstrin like proteiny domain-containing family A member 1| RGD1564153| tandem PH domain containing protein-1| tandem PH domain-containing protein 1| TAPP1| TAPP-1| TREES_T100012922| UY3_11173| Y1Q_026170| Y956_01302| plekha1

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved