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  3. PLCG2

PLCG2 (Phospholipase C gamma 2)

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The Function of PLCG2

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.

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Protein names

Recommended name:

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

Short name:

PLC-IV

Alternative name(s):

Phosphoinositide phospholipase C-gamma-2
Phospholipase C-IV
Phospholipase C-gamma-2
PLC-gamma-2

PLCG2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS3813009 (PLCG2) ??
  2. RS7192724 (PLCG2) ??

Top Gene-Substance Interactions

Substances That Increase PLCG2

Substances Interaction Organism Category

Substances That Decrease PLCG2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • AP-1
  • c-Jun
  • NF-kappaB1

Molecular Function:

  • Phosphatidylinositol Phospholipase C Activity
  • Phospholipase C Activity
  • Signal Transducer Activity

Biological Processes:

  • Activation Of Store-Operated Calcium Channel Activity
  • B Cell Differentiation
  • B Cell Receptor Signaling Pathway
  • Calcium-Mediated Signaling
  • Fc-Epsilon Receptor Signaling Pathway
  • Fc-Gamma Receptor Signaling Pathway Involved In Phagocytosis
  • Follicular B Cell Differentiation
  • Inositol Phosphate Metabolic Process
  • Inositol Trisphosphate Biosynthetic Process
  • Negative Regulation Of Programmed Cell Death
  • Phosphatidylinositol Biosynthetic Process
  • Phospholipid Catabolic Process
  • Platelet Activation
  • Positive Regulation Of Receptor Internalization
  • Positive Regulation Of Type I Interferon Production
  • Regulation Of Gene Expression
  • Release Of Sequestered Calcium Ion Into Cytosol
  • Response To Lipopolysaccharide
  • Stimulatory C-Type Lectin Receptor Signaling Pathway
  • T Cell Receptor Signaling Pathway
  • Wnt Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| phosphoinositide phospholipase C| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2| 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2| 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2-like protein| A306_01747| Anapl_05394| APLAID| AS27_11388| CB1_000711014| FCAS3| fj85b03| I79_000293| M91_05645| M959_02635| MDA_GLEAN10016407| N300_03420| N301_11753| N303_10109| N305_02420| N307_00340| N308_04459| N311_02101| N312_12680| N321_04352| N322_05042| N325_04474| N328_09950| N330_09780| N332_12459| N333_03397| N334_08692| N341_01035| PAL_GLEAN10016148| PANDA_006125| phosphatidylinositol-specific phospholipase C| phosphoinositide phospholipase C-gamma-2| phospholipase C, gamma 2| phospholipase C, gamma 2 (phosphatidylinositol-specific)| phospholipase C-IV| Plcg-2| PLCgamma2| PLC-gamma-2| PLC-IV| TREES_T100001625| UY3_06555| Y1Q_031391| Z169_09456| plcg2

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