The Function of PLCG2
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.
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Protein names
Recommended name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2Short name:
PLC-IVAlternative name(s):
Phosphoinositide phospholipase C-gamma-2Phospholipase C-IV
Phospholipase C-gamma-2
PLC-gamma-2
- RS3813009 (PLCG2) ??
- RS7192724 (PLCG2) ??
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Top Gene-Substance Interactions
Substances That Increase PLCG2
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Substances That Decrease PLCG2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Molecular Function:
Biological Processes:
- Activation Of Store-Operated Calcium Channel Activity
- B Cell Differentiation
- B Cell Receptor Signaling Pathway
- Calcium-Mediated Signaling
- Fc-Epsilon Receptor Signaling Pathway
- Fc-Gamma Receptor Signaling Pathway Involved In Phagocytosis
- Follicular B Cell Differentiation
- Inositol Phosphate Metabolic Process
- Inositol Trisphosphate Biosynthetic Process
- Negative Regulation Of Programmed Cell Death
- Phosphatidylinositol Biosynthetic Process
- Phospholipid Catabolic Process
- Platelet Activation
- Positive Regulation Of Receptor Internalization
- Positive Regulation Of Type I Interferon Production
- Regulation Of Gene Expression
- Release Of Sequestered Calcium Ion Into Cytosol
- Response To Lipopolysaccharide
- Stimulatory C-Type Lectin Receptor Signaling Pathway
- T Cell Receptor Signaling Pathway
- Wnt Signaling Pathway