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  3. PLAU

PLAU (Plasminogen activator, urokinase)

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The Function of PLAU

Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

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Protein names

Recommended name:

Urokinase-type plasminogen activator

Alternative name(s):

U-plasminogen activator
uPA

PLAU SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2227551 (PLAU) ??
  2. RS2227564 (PLAU) ??
  3. RS2688608 (PLAU) ??

Top Gene-Substance Interactions

PLAU Interacts with These Diseases

Disease Score

Substances That Increase PLAU

Substances Interaction Organism Category

Substances That Decrease PLAU

Substances Interaction Organism Category

Advanced Summary

Plasminogen activator, urokinase (PLAU), or urokinase-plasminogen activator (UPA).

PLAU gene encodes for a protein the converts an inactive protein plasminogen to the active form, plasmin [R]. Plasmin is a blood enzyme that degrades many blood plasma proteins and fibrin clots [R].

PLAU plays a role in the breakdown of fibrin, inflammation, tumor growth, and angiogenesis (the growth of new blood vessels from existing ones) [R].

The PLAU protein is processed through multiple forms before reaching its active state [R]. Certain mutations in the PLAU gene can keep the PLAU protein from transitioning to the active form [R].

An inactive form of the PLAU protein can bind to the PLAU receptor and trigger cell migration [R], degradation of the extracellular matrix, and tissue inflammation [R].These functions have been associated with wound healing and tumor cell metastasis [R].

Mutations in the PLAU gene have been associated with a number of diseases, including Quebec platelet disorder, late-onset Alzheimer’s disease, and many cancers [R].

In Quebec Platelet Disorder, PLAU is overproduced, causing increased and/or delayed bleeding [R1, R2].

In late-onset Alzheimer’s disease, a variation in PLAU keeps plasmin from breaking down certain proteins that cause the disease [R].

Evidence suggests an association with PLAU gene variations and asthma [R].

PLAU has been implicated in susceptibility to many cancers and in resistance to many cancer treatments [R].

Increased PLAU production has been implicated in atherosclerosis [R], myocardial infarction, [R], and mitral valve prolapse  [R].

Potential Fixes:

PLAU provides a potential target for future gene therapy research and cancer drug research [R].

Treatment for PLAU induced Quebec syndrome involves fibrinolytic inhibitor therapy [R]

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • AP-1
  • RORalpha2
  • c-Jun
  • Sp1
  • AP-2gamma
  • Fra-1

Tissue specificity:

Expressed in the prostate gland and prostate cancers.

Gene Pathways:

  • Hemostasis
  • Complement and coagulation cascades

Enzyme Regulation:

Inhibited by SERPINA5.

Molecular Function:

  • Serine-Type Endopeptidase Activity

Biological Processes:

  • Blood Coagulation
  • Chemotaxis
  • Fibrinolysis
  • Positive Regulation Of Cell Migration
  • Proteolysis
  • Regulation Of Cell Adhesion Mediated By Integrin
  • Regulation Of Cell Proliferation
  • Regulation Of Receptor Activity
  • Regulation Of Smooth Muscle Cell-Matrix Adhesion
  • Regulation Of Smooth Muscle Cell Migration
  • Regulation Of Wound Healing
  • Response To Hypoxia
  • Signal Transduction
  • Smooth Muscle Cell Migration
  • Angiogenesis
  • Cellular Response To Fluid Shear Stress
  • Cellular Response To Glucose Stimulus
  • Cellular Response To Hepatocyte Growth Factor Stimulus
  • Cellular Response To Hypoxia
  • Cellular Response To Lipopolysaccharide
  • Cellular Response To Staurosporine
  • Embryo Implantation
  • Neuron Death
  • Positive Regulation Of Cell Proliferation
  • Positive Regulation Of Ovulation
  • Positive Regulation Of Reactive Oxygen Species Metabolic Process
  • Positive Regulation Of Smooth Muscle Cell Migration
  • Regulation Of Hepatocyte Proliferation
  • Response To Hyperoxia
  • Skeletal Muscle Tissue Regeneration
  • Spermatogenesis

Drug Bank:

  • Urokinase
  • Amiloride
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| ATF| AS27_02520| AS28_05958| BDPLT5| CB1_000110016| D623_10029146| H920_01652| I79_002178| M959_03543| MDA_GLEAN10020899| N300_11810| N301_10728| N303_09268| N305_02713| N306_10547| N307_06062| N308_00250| N309_04335| N324_07957| N327_10856| N330_07072| N331_05705| N332_04624| N335_10256| N339_09100| N340_14893| N341_08591| PAL_GLEAN10020488| PANDA_009167| plasminogen activator, urinary| QPD| TREES_T100020048| u-PA| UPA| UPAM| U-plasminogen activator| urinary plasminogen activator| Urinary plasminogen activator, urokinase| URK| urokinase plasminogen activator| urokinase plasminogen activator preproprotein| urokinase type plasminogen activator| urokinase-type plasminogen activator| urokinase-type plasminogen activator isoform 1 preproprotein| urokinase-type plasminogen activator-like protein| UY3_04867| Y1Q_023181| Y956_09063| Z169_12732| plau

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