Disease	Score

Substances	Interaction	Organism	Category

Substances	Interaction	Organism	Category

Plasminogen activator, urokinase (PLAU), or urokinase-plasminogen activator (UPA).

PLAU gene encodes for a protein the converts an inactive protein plasminogen to the active form, plasmin [R]. Plasmin is a blood enzyme that degrades many blood plasma proteins and fibrin clots [R].

PLAU plays a role in the breakdown of fibrin, inflammation, tumor growth, and angiogenesis (the growth of new blood vessels from existing ones) [R].

The PLAU protein is processed through multiple forms before reaching its active state [R]. Certain mutations in the PLAU gene can keep the PLAU protein from transitioning to the active form [R].

An inactive form of the PLAU protein can bind to the PLAU receptor and trigger cell migration [R], degradation of the extracellular matrix, and tissue inflammation [R].These functions have been associated with wound healing and tumor cell metastasis [R].

Mutations in the PLAU gene have been associated with a number of diseases, including Quebec platelet disorder, late-onset Alzheimer’s disease, and many cancers [R].

In Quebec Platelet Disorder, PLAU is overproduced, causing increased and/or delayed bleeding [R1, R2].

In late-onset Alzheimer’s disease, a variation in PLAU keeps plasmin from breaking down certain proteins that cause the disease [R].

Evidence suggests an association with PLAU gene variations and asthma [R].

PLAU has been implicated in susceptibility to many cancers and in resistance to many cancer treatments [R].

Increased PLAU production has been implicated in atherosclerosis [R], myocardial infarction, [R], and mitral valve prolapse  [R].

Potential Fixes:

PLAU provides a potential target for future gene therapy research and cancer drug research [R].

Treatment for PLAU induced Quebec syndrome involves fibrinolytic inhibitor therapy [R]

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

The following transcription factors affect gene expression:

• AP-1
• c-Jun
• Fra-1
• Sp1
• AP-2gamma
• RORalpha2

Tissue specificity:

Expressed in the prostate gland and prostate cancers.

Enzyme Regulation:

Inhibited by SERPINA5.

Molecular Function:

• Serine-Type Endopeptidase Activity

Biological Processes:

• Angiogenesis
• Response To Hypoxia
• Proteolysis
• Chemotaxis
• Signal Transduction
• Spermatogenesis
• Embryo Implantation
• Blood Coagulation
• Positive Regulation Of Cell Proliferation
• Regulation Of Receptor Activity
• Smooth Muscle Cell Migration
• Regulation Of Smooth Muscle Cell Migration
• Positive Regulation Of Smooth Muscle Cell Migration
• Positive Regulation Of Cell Migration
• Regulation Of Cell Adhesion Mediated By Integrin
• Cellular Response To Hepatocyte Growth Factor Stimulus
• Regulation Of Cell Proliferation
• Fibrinolysis
• Skeletal Muscle Tissue Regeneration
• Response To Hyperoxia
• Positive Regulation Of Ovulation
• Regulation Of Wound Healing
• Neuron Death
• Cellular Response To Lipopolysaccharide
• Cellular Response To Glucose Stimulus
• Cellular Response To Hypoxia
• Cellular Response To Fluid Shear Stress
• Cellular Response To Staurosporine
• Regulation Of Smooth Muscle Cell-Matrix Adhesion
• Regulation Of Hepatocyte Proliferation
• Positive Regulation Of Reactive Oxygen Species Metabolic Process

Drug Bank:

• Urokinase
• Amiloride

*synonyms