The Function of PLA2G4F
Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Has higher enzyme activity for phosphatidylethanolamine than phosphatidylcholine.
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Protein names
Recommended name:
Cytosolic phospholipase A2 zetaAlternative name(s):
cPLA2-zetaPhospholipase A2 group IVF
- RS1356410 (PLA2G4F) ??
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Top Gene-Substance Interactions
Substances That Increase PLA2G4F
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Substances That Decrease PLA2G4F
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Enzyme Regulation:
Stimulated by cytosolic Ca(2+).
Molecular Function:
- Calcium-Dependent Phospholipase A2 Activity
- Lysophospholipase Activity
- Metal Ion Binding
- Phosphatidylcholine 1-Acylhydrolase Activity
- Phospholipase A2 Activity
Biological Processes:
- Arachidonic Acid Secretion
- Cellular Response To Antibiotic
- Cellular Response To Organic Cyclic Compound
- Phosphatidylcholine Acyl-Chain Remodeling
- Phosphatidylethanolamine Acyl-Chain Remodeling
- Phosphatidylglycerol Acyl-Chain Remodeling
- Phosphatidylinositol Acyl-Chain Remodeling
- Phosphatidylserine Acyl-Chain Remodeling
- Phospholipid Catabolic Process
- Phospholipid Metabolic Process
- Prostaglandin Biosynthetic Process