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  3. PLA2G4A

PLA2G4A (Phospholipase A2 group IVA)

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The Function of PLA2G4A

Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.

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Protein names

Recommended name:

Cytosolic phospholipase A2

Alternative name(s):

cPLA2
Phospholipase A2 group IVA
Phosphatidylcholine 2-acylhydrolase

PLA2G4A SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10798069 (PLA2G4A) ??
  2. RS114333818 (PLA2G4A) ??
  3. RS12720541 (PLA2G4A) ??
  4. RS12746200 (PLA2G4A) ??
  5. RS4140564 (PLA2G4A) ??

Top Gene-Substance Interactions

PLA2G4A Interacts with These Diseases

Disease Score

Substances That Increase PLA2G4A

Substances Interaction Organism Category

Substances That Decrease PLA2G4A

Substances Interaction Organism Category

Advanced Summary

     From UniProt: PLA2G4A mutations resulting in phospholipase A2 deficiency have been found in a patient affected by recurrent episodes of multiple complicated ulcers of the small intestine, not due to cyclooxygenase inhibitors use. Disease features also include platelet dysfunction, and globally decreased eicosanoid synthesis (PubMed:18451993).

     From NCBI Gene: This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015] From UniProt: Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • PPAR-gamma1
  • PPAR-gamma2
  • GR
  • GR-alpha
  • GR-beta
  • AP-1
  • c-Jun
  • NF-kappaB1
  • Sp1

Tissue specificity:

Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung endothelium.

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • MAPK signaling pathway
  • Signal Transduction
  • Linoleic acid metabolism
  • Fat digestion and absorption
  • Hemostasis
  • Pancreatic secretion
  • Vascular smooth muscle contraction
  • Toxoplasmosis
  • Arachidonic acid metabolism
  • Glutamatergic synapse
  • Long-term depression
  • VEGF signaling pathway
  • GnRH signaling pathway
  • Fc epsilon RI signaling pathway
  • Glycerophospholipid metabolism
  • alpha-Linolenic acid metabolism
  • Ether lipid metabolism

Enzyme Regulation:

Stimulated by agonists such as ATP, EGF, thrombin and bradykinin as well as by cytosolic Ca(2+).

Molecular Function:

  • Calcium-Dependent Phospholipase A2 Activity
  • Calcium-Dependent Phospholipid Binding
  • Calcium Ion Binding
  • Lysophospholipase Activity
  • Phosphatidylcholine 1-Acylhydrolase Activity
  • Phospholipase A2 Activity

Biological Processes:

  • Arachidonic Acid Metabolic Process
  • Arachidonic Acid Secretion
  • Cardiolipin Acyl-Chain Remodeling
  • Cellular Response To Antibiotic
  • Icosanoid Biosynthetic Process
  • Icosanoid Metabolic Process
  • Phosphatidic Acid Biosynthetic Process
  • Phosphatidylcholine Acyl-Chain Remodeling
  • Phosphatidylethanolamine Acyl-Chain Remodeling
  • Phosphatidylglycerol Acyl-Chain Remodeling
  • Phosphatidylinositol Acyl-Chain Remodeling
  • Phosphatidylserine Acyl-Chain Remodeling
  • Phospholipid Catabolic Process
  • Phospholipid Metabolic Process
  • Platelet Activating Factor Biosynthetic Process
  • Regulation Of Cell Proliferation
  • Aging
  • Decidualization
  • Luteolysis
  • Ovulation From Ovarian Follicle
  • Positive Regulation Of Apoptotic Process
  • Positive Regulation Of Bone Mineralization
  • Positive Regulation Of Cell Proliferation
  • Positive Regulation Of Fever Generation
  • Positive Regulation Of Prostaglandin Biosynthetic Process
  • Positive Regulation Of Vesicle Fusion
  • Response To Calcium Ion
  • Response To Glucocorticoid
  • Response To Heat
  • Response To Hydrogen Peroxide
  • Response To Lipopolysaccharide
  • Response To Lithium Ion
  • Response To Methylmercury
  • Response To Organonitrogen Compound
  • Response To Vitamin D
  • Surfactant Homeostasis

Drug Bank:

  • Fluticasone Propionate
  • Carbachol
  • Carbenicillin
  • Epirubicin
  • Niflumic Acid
  • Orlistat
  • Quinacrine
  • Streptokinase
  • Suramin
  • Aldesleukin
  • Fluocinolone Acetonide
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| lysophospholipase| CPLA2| A306_11742| Anapl_16692| AS27_12713| AS28_06003| calcium-dependent phospholipid-binding protein| CB1_000818011| cPLA2alpha| cPLA2-alpha| cytosolic calcium-dependent phospholipase A2| cytosolic phospholipase A2| Cytosolic phospholipase A2 (CPLA2)| cytosolic phospholipase A2, group IVA| cytosolic PLA2| D623_10007704| EGK_01844| group IVA phospholipase A2| GW7_07099| H920_10021| M959_12539| MDA_GLEAN10017470| N300_14683| N301_05347| N302_03592| N305_10958| N306_00798| N307_07899| N308_02140| N311_02459| N312_02079| N320_00377| N322_02225| N324_11940| N325_11742| N326_01006| N328_11409| N329_03716| N330_14246| N331_06519| N332_06566| N333_07121| N335_14008| N340_00656| PAL_GLEAN10017646| PANDA_014302| phosphatidylcholine 2-acylhydrolase| phosphatidyl choline 2-acylhydrolase cPLA2| phospholipase A2 cytosolic| phospholipase A2, group 4| phospholipase A2, group IB (pancreas)| phospholipase A2, group IVA (cytosolic, calcium-dependent)| PLA2| Pla2c| PLA2G1B| PLA2G4| TREES_T100016373| Type IV PLA2| UY3_04101| Y1Q_013468| Y956_06385| Z169_07311| pla2g4a

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