• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. PLA2G12A

PLA2G12A (Phospholipase A2 group XIIA)

Loading...

The Function of PLA2G12A

PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or -phosphatidylethanolamine.

0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

Group XIIA secretory phospholipase A2

Alternative name(s):

GXII sPLA2
sPLA2-XII
Phosphatidylcholine 2-acylhydrolase 12A

PLA2G12A SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2285714 (PLA2G12A) ??

Top Gene-Substance Interactions

Substances That Increase PLA2G12A

Substances Interaction Organism Category

Substances That Decrease PLA2G12A

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CUTL1
  • HNF-1A
  • HNF-1
  • C/EBPbeta
  • c-Myc

Tissue specificity:

Abundantly expressed in heart, skeletal muscle, kidney, liver and pancreas.

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • MAPK signaling pathway
  • Linoleic acid metabolism
  • Fat digestion and absorption
  • Pancreatic secretion
  • Vascular smooth muscle contraction
  • Toxoplasmosis
  • Arachidonic acid metabolism
  • Glutamatergic synapse
  • Long-term depression
  • VEGF signaling pathway
  • GnRH signaling pathway
  • Fc epsilon RI signaling pathway
  • Glycerophospholipid metabolism
  • alpha-Linolenic acid metabolism
  • Ether lipid metabolism

Cofactor:

Binds 1 Ca(2+) ion per subunit.

Molecular Function:

  • Calcium-Dependent Phospholipase A2 Activity
  • Calcium Ion Binding
  • Phospholipase A2 Activity

Biological Processes:

  • Arachidonic Acid Secretion
  • Lipid Catabolic Process
  • Phosphatidic Acid Biosynthetic Process
  • Phosphatidylcholine Acyl-Chain Remodeling
  • Phosphatidylethanolamine Acyl-Chain Remodeling
  • Phosphatidylglycerol Acyl-Chain Remodeling
  • Phosphatidylinositol Acyl-Chain Remodeling
  • Phosphatidylserine Acyl-Chain Remodeling
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AS27_15617| AS28_08372| EGK_16009| group XII-1 phospholipase A2| group XIIA secreted phospholipase A2| group XIIA secretory phospholipase A2| group XIIA secretory phospholipase A2-like protein| group XII secreted phospholipase A2| GXII| GXII-1| GXII-1-PLA2| GXII sPLA2| H920_12751| M91_06093| M959_14619| MDA_GLEAN10003403| mGXII-1| N300_05145| N301_12554| N302_04260| N303_01848| N305_00553| N306_00984| N307_12327| N308_12120| N309_00321| N310_05575| N311_07317| N312_09247| N321_04718| N322_00379| N324_05776| N325_10401| N326_05567| N327_01353| N328_11040| N329_05525| N330_11159| N331_05708| N332_12132| N333_00157| N334_12972| N335_05461| N336_00103| N339_01959| N340_09499| N341_10543| PAL_GLEAN10022609| PANDA_019551| phosphatidylcholine 2-acylhydrolase 12A| phospholipase A2 group 12| phospholipase A2, group XII| phospholipase A2, group XIIA| PLA2G12| PLA2 group XII| Rossy| sPLA2-XII| TREES_T100005699| Y1Q_002793| Y956_00912| Z169_09986| pla2g12a

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved