The Function of PLA2G12A
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or -phosphatidylethanolamine.
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Protein names
Recommended name:
Group XIIA secretory phospholipase A2Alternative name(s):
GXII sPLA2sPLA2-XII
Phosphatidylcholine 2-acylhydrolase 12A
- RS2285714 (PLA2G12A) ??
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Top Gene-Substance Interactions
Substances That Increase PLA2G12A
| Substances | Interaction | Organism | Category |
Substances That Decrease PLA2G12A
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Abundantly expressed in heart, skeletal muscle, kidney, liver and pancreas.
Gene Pathways:
- Metabolic pathways
- Metabolism
- MAPK signaling pathway
- Linoleic acid metabolism
- Fat digestion and absorption
- Pancreatic secretion
- Vascular smooth muscle contraction
- Toxoplasmosis
- Arachidonic acid metabolism
- Glutamatergic synapse
- Long-term depression
- VEGF signaling pathway
- GnRH signaling pathway
- Fc epsilon RI signaling pathway
- Glycerophospholipid metabolism
- alpha-Linolenic acid metabolism
- Ether lipid metabolism
Cofactor:
Binds 1 Ca(2+) ion per subunit.
Molecular Function:
Biological Processes:
- Phosphatidic Acid Biosynthetic Process
- Lipid Catabolic Process
- Phosphatidylglycerol Acyl-Chain Remodeling
- Phosphatidylinositol Acyl-Chain Remodeling
- Phosphatidylserine Acyl-Chain Remodeling
- Phosphatidylcholine Acyl-Chain Remodeling
- Phosphatidylethanolamine Acyl-Chain Remodeling
- Arachidonic Acid Secretion