The Function of PKM
Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
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Protein names
Recommended name:
Pyruvate kinase PKMAlternative name(s):
Cytosolic thyroid hormone-binding proteinCTHBP
Opa-interacting protein 3
OIP-3
Pyruvate kinase 2/3
Pyruvate kinase muscle isozyme
Thyroid hormone-binding protein 1
THBP1
Tumor M2-PK
p58
- RS113920924 (PKM) ??
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Top Gene-Substance Interactions
PKM Interacts with These Diseases
| Disease | Score |
Substances That Increase PKM
| Substances | Interaction | Organism | Category |
Substances That Decrease PKM
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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