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PKM (Pyruvate kinase, muscle)

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The Function of PKM

Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.

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Protein names

Recommended name:

Pyruvate kinase PKM

Alternative name(s):

Cytosolic thyroid hormone-binding protein
CTHBP
Opa-interacting protein 3
OIP-3
Pyruvate kinase 2/3
Pyruvate kinase muscle isozyme
Thyroid hormone-binding protein 1
THBP1
Tumor M2-PK
p58

PKM SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS113920924 (PKM) ??

Top Gene-Substance Interactions

PKM Interacts with These Diseases

Disease Score

Substances That Increase PKM

Substances Interaction Organism Category

Substances That Decrease PKM

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

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