The Function of PITX2
Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach. Isoform PTX2C is involved in left-right asymmetry the developing embryo.
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Protein names
Recommended name:
Pituitary homeobox 2Alternative name(s):
ALL1-responsive protein ARP1Homeobox protein PITX2
Paired-like homeodomain transcription factor 2
RIEG bicoid-related homeobox transcription factor
Solurshin
- RS10033464 (PITX2) ??
- RS12646447 (PITX2) ??
- RS17042171 (PITX2) ??
- RS2200733 (PITX2) ??
- RS3853444 (PITX2) ??
- RS6817105 (PITX2) ??
- RS6843082 (PITX2) ??
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Top Gene-Substance Interactions
PITX2 Interacts with These Diseases
| Disease | Score |
Substances That Increase PITX2
| Substances | Interaction | Organism | Category |
Substances That Decrease PITX2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Transcription Regulatory Region Sequence-Specific Dna Binding
- Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Transcriptional Repressor Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Rna Polymerase Ii Transcription Factor Binding
- Rna Polymerase Ii Activating Transcription Factor Binding
- Rna Polymerase Ii Transcription Coactivator Activity
- Transcriptional Repressor Activity, Rna Polymerase Ii Transcription Factor Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Factor Binding
- Chromatin Dna Binding
- Identical Protein Binding
- Protein Homodimerization Activity
- Ribonucleoprotein Complex Binding
- Phosphoprotein Binding
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Branching Involved In Blood Vessel Morphogenesis
- Vasculogenesis
- In Utero Embryonic Development
- Neuron Migration
- Extraocular Skeletal Muscle Development
- Atrioventricular Valve Development
- Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis
- Pulmonary Myocardium Development
- Regulation Of Transcription, Dna-Templated
- Regulation Of Transcription From Rna Polymerase Ii Promoter
- Determination Of Left/Right Symmetry
- Myoblast Fusion
- Male Gonad Development
- Female Gonad Development
- Response To Hormone
- Wnt Signaling Pathway
- Subthalamic Nucleus Development
- Hypothalamus Cell Migration
- Regulation Of Cell Migration
- Embryonic Camera-Type Eye Development
- Response To Vitamin A
- Embryonic Hindlimb Morphogenesis
- Hair Cell Differentiation
- Vascular Smooth Muscle Cell Differentiation
- Deltoid Tuberosity Development
- Odontogenesis Of Dentin-Containing Tooth
- Odontogenesis
- Camera-Type Eye Development
- Positive Regulation Of Dna Binding
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Spleen Development
- Embryonic Digestive Tract Morphogenesis
- Atrial Cardiac Muscle Tissue Morphogenesis
- Ventricular Cardiac Muscle Cell Development
- Somatotropin Secreting Cell Differentiation
- Prolactin Secreting Cell Differentiation
- Ventricular Septum Morphogenesis
- Left Lung Morphogenesis
- Pulmonary Vein Morphogenesis
- Superior Vena Cava Morphogenesis
- Endodermal Digestive Tract Morphogenesis
- Iris Morphogenesis
- Cell Proliferation Involved In Outflow Tract Morphogenesis
- Left/Right Axis Specification
- Positive Regulation Of Myoblast Proliferation