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  3. PITX2

PITX2 (Paired like homeodomain 2)

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The Function of PITX2

Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach. Isoform PTX2C is involved in left-right asymmetry the developing embryo.

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Protein names

Recommended name:

Pituitary homeobox 2

Alternative name(s):

ALL1-responsive protein ARP1
Homeobox protein PITX2
Paired-like homeodomain transcription factor 2
RIEG bicoid-related homeobox transcription factor
Solurshin

PITX2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10033464 (PITX2) ??
  2. RS12646447 (PITX2) ??
  3. RS17042171 (PITX2) ??
  4. RS2200733 (PITX2) ??
  5. RS254560 (PITX2) ??
  6. RS3853444 (PITX2) ??
  7. RS6817105 (PITX2) ??
  8. RS6843082 (PITX2) ??

Top Gene-Substance Interactions

PITX2 Interacts with These Diseases

Disease Score

Substances That Increase PITX2

Substances Interaction Organism Category

Substances That Decrease PITX2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Pax-6
  • MEF-2A
  • Zic1
  • Brachyury

Gene Pathways:

  • TGF-beta signaling pathway

Molecular Function:

  • Chromatin Dna Binding
  • Identical Protein Binding
  • Phosphoprotein Binding
  • Protein Homodimerization Activity
  • Ribonucleoprotein Complex Binding
  • Rna Polymerase Ii Activating Transcription Factor Binding
  • Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
  • Rna Polymerase Ii Transcription Coactivator Activity
  • Rna Polymerase Ii Transcription Factor Binding
  • Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
  • Transcriptional Repressor Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
  • Transcriptional Repressor Activity, Rna Polymerase Ii Transcription Factor Binding
  • Transcription Factor Activity, Sequence-Specific Dna Binding
  • Transcription Factor Binding
  • Transcription Regulatory Region Sequence-Specific Dna Binding

Biological Processes:

  • Atrial Cardiac Muscle Tissue Morphogenesis
  • Atrioventricular Valve Development
  • Camera-Type Eye Development
  • Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis
  • Cell Proliferation Involved In Outflow Tract Morphogenesis
  • Deltoid Tuberosity Development
  • Determination Of Left/Right Symmetry
  • Embryonic Camera-Type Eye Development
  • Embryonic Digestive Tract Morphogenesis
  • Embryonic Hindlimb Morphogenesis
  • Endodermal Digestive Tract Morphogenesis
  • Extraocular Skeletal Muscle Development
  • Female Gonad Development
  • Hair Cell Differentiation
  • Hypothalamus Cell Migration
  • In Utero Embryonic Development
  • Iris Morphogenesis
  • Left/Right Axis Specification
  • Left Lung Morphogenesis
  • Male Gonad Development
  • Myoblast Fusion
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Neuron Migration
  • Odontogenesis
  • Odontogenesis Of Dentin-Containing Tooth
  • Branching Involved In Blood Vessel Morphogenesis
  • Positive Regulation Of Dna Binding
  • Positive Regulation Of Myoblast Proliferation
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Prolactin Secreting Cell Differentiation
  • Pulmonary Myocardium Development
  • Pulmonary Vein Morphogenesis
  • Regulation Of Cell Migration
  • Regulation Of Transcription, Dna-Templated
  • Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Response To Hormone
  • Response To Vitamin A
  • Somatotropin Secreting Cell Differentiation
  • Spleen Development
  • Subthalamic Nucleus Development
  • Superior Vena Cava Morphogenesis
  • Vascular Smooth Muscle Cell Differentiation
  • Vasculogenesis
  • Ventricular Cardiac Muscle Cell Development
  • Ventricular Septum Morphogenesis
  • Wnt Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| null| arp1| ptx2| RS| paired-like homeodomain 1| paired-like homeodomain transcription factor 1| all1-responsive gene 1| ALL1-responsive protein ARP1| Anapl_12253| AS27_15624| AS28_08364| brx1| Brx1b| BRX1 homeoprotein| CB1_001498001| cPITX2| D623_10030573| EGK_16019| H920_12740| homeobox protein PITX2| homeodomain transcription factor 2| IDG2| IGDS| IGDS2| IHG2| IRID2| M959_05186| MDA_GLEAN10008441| Munc30| N300_05153| N301_12544| N302_04268| N303_01840| N305_00543| N306_00974| N307_12335| N308_12129| N309_14646| N312_07620| orthodenticle-like homeobox 2| Otlx2| paired-like homeodomain 2| paired like homeodomain transcription factor 2| paired-like homeodomain transcription factor 2| paired-like homeodomain transcription factor 2a| paired-like homeodomain transcription factor 2alpha| paired-like homeodomain transcription factor 2c| paired-like homeodomain transcription factor Munc 30| PAL_GLEAN10022616| PANDA_005886| Pituitary homeobox 2| pituitary homeobox transcription factor| PITX1| Pitx-2| pitx2a| pitx2-A| pitx2b| pitx2-b| Pitx2c| RGS| Rieg| RIEG1| rieg bicoid-related homeobox transcription factor 1| rPtx2| solurshin| transcription factor Pitx2| TREES_T100005696| UY3_01926| xpitx2| xPtx2| Y1Q_013345| Y956_00904| Z169_09996| pitx2

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