The Function of PIK3CD
Phosphoinositide-3-kinase (PI3K) that phosphorylates PftdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Mediates TCR signaling events at the immune synapse. Activation by TCR leads to antigen-dependent memory T-cell migration and retention to antigenic tissues. Together with PIK3CG participates in T-cell development. Contributes to T-helper cell expansion and differentiation. Required for T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigen dependent recruitment of T-cells. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in NK cell receptor activation. Have a role in NK cell maturation and cytokine production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation. Together with PIK3CG participates in neutrophil respiratory burst. Have important roles in mast-cell development and mast cell mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion and migration. Required for allergen-IgE-induced degranulation and cytokine release. The lipid kinase activity is required for its biological function. Isoform 2 may be involved in stabilizing total RAS levels, resulting in increased ERK phosphorylation and increased PI3K activity.
Protein names
Recommended name:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformAlternative name(s):
PI3-kinase subunit deltaPI3K-delta
PI3Kdelta
PtdIns-3-kinase subunit delta
Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta
PtdIns-3-kinase subunit p110-delta
p110delta
- RS14271 (PIK3CD) ??
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Top Gene-Substance Interactions
PIK3CD Interacts with These Diseases
| Disease | Score |
Substances That Increase PIK3CD
| Substances | Interaction | Organism | Category |
Substances That Decrease PIK3CD
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Isoform 2 is expressed in normal thymus, lung and spleen tissues, and is detected at low levels in normal lysates from colon and ovarian biopsies, at elevated levels in lysates from colorectal tumors and is abundantly expressed in some ovarian tumors (at protein level). Both isoform 1 and isoform 2 are widely expressed. Isoform 1 is expressed predominantly in leukocytes.
Gene Pathways:
- Metabolism
- Disease
- Immune System
- Melanoma
- Pathways in cancer
- Regulation of actin cytoskeleton
- Signal Transduction
- Hepatitis C
- Jak-STAT signaling pathway
- Measles
- Natural killer cell mediated cytotoxicity
- Toll-like receptor signaling pathway
- Bacterial invasion of epithelial cells
- Colorectal cancer
- Endometrial cancer
- Leukocyte transendothelial migration
- Prostate cancer
- Chemokine signaling pathway
- Neurotrophin signaling pathway
- T cell receptor signaling pathway
- Acute myeloid leukemia
- Apoptosis
- B cell receptor signaling pathway
- Chagas disease (American trypanosomiasis)
- Chronic myeloid leukemia
- Glioma
- Inositol phosphate metabolism
- Insulin signaling pathway
- Osteoclast differentiation
- Pancreatic cancer
- Phosphatidylinositol signaling system
- Small cell lung cancer
- Toxoplasmosis
- Aldosterone-regulated sodium reabsorption
- Amoebiasis
- mTOR signaling pathway
- Progesterone-mediated oocyte maturation
- Renal cell carcinoma
- VEGF signaling pathway
- Fc epsilon RI signaling pathway
- Type II diabetes mellitus
- Non-small cell lung cancer
- Carbohydrate digestion and absorption
Enzyme Regulation:
Activated by growth factors and cytokine receptors through a tyrosine-kinase-dependent mechanism. Activated by RAS. IC87114 inhibits lipid kinase activity and is selective in cells at doses up to 5-10 uM. IC87114 blocks T-cell receptor signaling in naive and memory T-cells and reduces cytokine production by memory T-cells.
Molecular Function:
- Atp Binding
- 1-Phosphatidylinositol-3-Kinase Activity
- Phosphatidylinositol 3-Kinase Activity
- 1-Phosphatidylinositol-4-Phosphate 3-Kinase Activity
- Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Activity
Biological Processes:
- Natural Killer Cell Differentiation
- Cytokine Production
- Adaptive Immune Response
- Mast Cell Chemotaxis
- Respiratory Burst Involved In Defense Response
- Protein Phosphorylation
- Phosphatidylinositol Biosynthetic Process
- Inflammatory Response
- Signal Transduction
- Positive Regulation Of Gene Expression
- T Cell Chemotaxis
- Phosphatidylinositol 3-Kinase Signaling
- Regulation Of Phosphatidylinositol 3-Kinase Signaling
- Phosphorylation
- Natural Killer Cell Activation
- T Cell Differentiation
- Positive Regulation Of Cell Migration
- Neutrophil Chemotaxis
- Natural Killer Cell Chemotaxis
- B Cell Chemotaxis
- T Cell Activation
- B Cell Activation
- Mast Cell Degranulation
- Innate Immune Response
- Phosphatidylinositol-Mediated Signaling
- T Cell Receptor Signaling Pathway
- B Cell Receptor Signaling Pathway
- Mast Cell Differentiation
- Neutrophil Extravasation