The Function of PIAS1
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB.
Protein names
Recommended name:
E3 SUMO-protein ligase PIAS1Short name:
GBPAlternative name(s):
DEAD/H box-binding protein 1Gu-binding protein
Protein inhibitor of activated STAT protein 1
RNA helicase II-binding protein
- RS338389 (PIAS1) ??
- RS448720 (PIAS1) ??
- RS4776997 (PIAS1) ??
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Top Gene-Substance Interactions
PIAS1 Interacts with These Diseases
| Disease | Score |
Substances That Increase PIAS1
| Substances | Interaction | Organism | Category |
Substances That Decrease PIAS1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in numerous tissues with highest level in testis.
Gene Pathways:
Molecular Function:
- Dna Binding
- Transcription Coactivator Activity
- Transcription Corepressor Activity
- Zinc Ion Binding
- Ligase Activity
- Sumo Transferase Activity
- Enzyme Binding
- Androgen Receptor Binding
- Sumo Ligase Activity
Biological Processes:
- G1/S Transition Of Mitotic Cell Cycle
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Transcription, Dna-Templated
- Jak-Stat Cascade
- Spermatogenesis
- Visual Learning
- Protein Sumoylation
- Androgen Receptor Signaling Pathway
- Positive Regulation Of Proteasomal Ubiquitin-Dependent Protein Catabolic Process
- Positive Regulation Of Protein Sumoylation
- Regulation Of Cell Proliferation
- Negative Regulation Of Apoptotic Process
- Fat Cell Differentiation
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Smooth Muscle Cell Differentiation
- Regulation Of Interferon-Gamma-Mediated Signaling Pathway
- Protein-Dna Complex Assembly