Protein names
Recommended name:
D-3-phosphoglycerate dehydrogenaseShort name:
3-PGDH- RS12144094 (PHGDH) ??
- RS477992 (PHGDH) ??
- RS478093 (PHGDH) ??
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Top Gene-Substance Interactions
PHGDH Interacts with These Diseases
| Disease | Score |
Substances That Increase PHGDH
| Substances | Interaction | Organism | Category |
Substances That Decrease PHGDH
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Induction:
Induced by 17-beta-estradiol (estrogenic ligand) and 4-hydroxytamoxifen (agonist/antagonist ligand). Positively regulated by the transcription factors SP1 and NF-Y.
Molecular Function:
Biological Processes:
- Brain Development
- G1 To G0 Transition
- Gamma-Aminobutyric Acid Metabolic Process
- Glial Cell Development
- Glutamine Metabolic Process
- Glycine Metabolic Process
- L-Serine Biosynthetic Process
- Neural Tube Development
- Neuron Projection Development
- Regulation Of Gene Expression
- Serine Family Amino Acid Biosynthetic Process
- Spinal Cord Development
- Taurine Metabolic Process
- Threonine Metabolic Process