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  3. PHGDH

PHGDH (Phosphoglycerate dehydrogenase)

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Protein names

Recommended name:

D-3-phosphoglycerate dehydrogenase

Short name:

3-PGDH

PHGDH SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS12144094 (PHGDH) ??
  2. RS477992 (PHGDH) ??
  3. RS478093 (PHGDH) ??

Top Gene-Substance Interactions

PHGDH Interacts with These Diseases

Disease Score

Substances That Increase PHGDH

Substances Interaction Organism Category

Substances That Decrease PHGDH

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • Max
  • NF-kappaB1
  • PPAR-alpha
  • STAT5A
  • IRF-1
  • GATA-3

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Glycine, serine and threonine metabolism

Induction:

Induced by 17-beta-estradiol (estrogenic ligand) and 4-hydroxytamoxifen (agonist/antagonist ligand). Positively regulated by the transcription factors SP1 and NF-Y.

Molecular Function:

  • Electron Carrier Activity
  • Nad Binding
  • Phosphoglycerate Dehydrogenase Activity

Biological Processes:

  • Brain Development
  • G1 To G0 Transition
  • Gamma-Aminobutyric Acid Metabolic Process
  • Glial Cell Development
  • Glutamine Metabolic Process
  • Glycine Metabolic Process
  • L-Serine Biosynthetic Process
  • Neural Tube Development
  • Neuron Projection Development
  • Regulation Of Gene Expression
  • Serine Family Amino Acid Biosynthetic Process
  • Spinal Cord Development
  • Taurine Metabolic Process
  • Threonine Metabolic Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| PGDH| NLS1| 3PGDH| 3-PGDH| 3-phosphoglycerate dehydrogenase| 3-phosphoglycerate dehyrogenase| 4930479N23| A10| A306_13476| AS27_15769| AS28_09911| CB1_000738019| D-3-phosphoglycerate dehydrogenase| d-3-phosphoglycerate dehydrogenase-like protein| D623_10011202| epididymis secretory protein Li 113| fb38f06| GW7_10423| H920_13579| HEL-S-113| M91_04626| M959_05828| MDA_GLEAN10024850| N300_02714| N301_09641| N302_00535| N303_11561| N305_12092| N307_15487| N309_10359| N310_00577| N330_07068| N332_06659| N333_02449| N340_03443| NLS| PAL_GLEAN10017474| PANDA_018382| PDG| PGAD| PGD| PHGDHD| QccE-21483| SERA| TREES_T100022016| UY3_08388| Y1Q_001332| Y956_03468| Z169_13483| phgdh

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