Summary of PFKP
PFKP (phosphofructokinase, platelet) encodes a protein that is a key regulatory enzyme in glycolysis (R).
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The Function of PFKP
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
Protein names
Recommended name:
ATP-dependent 6-phosphofructokinase, platelet typeShort name:
PFK-PAlternative name(s):
ATP-PFK6-phosphofructokinase type C
Phosphofructo-1-kinase isozyme C
PFK-C
Phosphohexokinase
- RS6602024 (PFKP) ??
- RS7896691 (PFKP) ??
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Top Gene-Substance Interactions
Substances That Increase PFKP
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Substances That Decrease PFKP
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Advanced Summary
PFKP (phosphofructokinase, platelet) encodes a protein that is a key regulatory enzyme in glycolysis (R).
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Enzyme Regulation:
Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
Molecular Function:
- 6-Phosphofructokinase Activity
- Atp Binding
- Protein Complex Binding
- Metal Ion Binding
- Cadherin Binding Involved In Cell-Cell Adhesion
Biological Processes:
- Fructose 6-Phosphate Metabolic Process
- Canonical Glycolysis
- Mitophagy In Response To Mitochondrial Depolarization