The Function of PFKM
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
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Protein names
Recommended name:
ATP-dependent 6-phosphofructokinase, muscle typeShort name:
PFK-MAlternative name(s):
ATP-PFK6-phosphofructokinase type A
Phosphofructo-1-kinase isozyme A
PFK-A
Phosphohexokinase
- RS10875746 (PFKM) ??
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Top Gene-Substance Interactions
PFKM Interacts with These Diseases
| Disease | Score |
Substances That Increase PFKM
| Substances | Interaction | Organism | Category |
Substances That Decrease PFKM
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Enzyme Regulation:
Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
Molecular Function:
- 6-Phosphofructokinase Activity
- Atp Binding
- Protein C-Terminus Binding
- Kinase Binding
- Identical Protein Binding
- Metal Ion Binding
- Fructose Binding
Biological Processes:
- Glycogen Catabolic Process
- Fructose 6-Phosphate Metabolic Process
- Glycolytic Process
- Positive Regulation Of Insulin Secretion
- Glucose Homeostasis
- Muscle Cell Cellular Homeostasis
- Protein Oligomerization
- Canonical Glycolysis
- Glycolysis From Storage Polysaccharide Through Glucose-1-Phosphate