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  3. PFKM

PFKM (Phosphofructokinase, muscle)

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The Function of PFKM

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.

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Protein names

Recommended name:

ATP-dependent 6-phosphofructokinase, muscle type

Short name:

PFK-M

Alternative name(s):

ATP-PFK
6-phosphofructokinase type A
Phosphofructo-1-kinase isozyme A
PFK-A
Phosphohexokinase

PFKM SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10875746 (PFKM) ??

Top Gene-Substance Interactions

PFKM Interacts with These Diseases

Disease Score

Substances That Increase PFKM

Substances Interaction Organism Category

Substances That Decrease PFKM

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Evi-1
  • AP-1
  • E2F-1
  • RelA

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Disease
  • Fructose and mannose metabolism
  • Glycolysis / Gluconeogenesis
  • Pentose phosphate pathway
  • Metabolism
  • Galactose metabolism

Enzyme Regulation:

Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.

Molecular Function:

  • 6-Phosphofructokinase Activity
  • Atp Binding
  • Fructose Binding
  • Identical Protein Binding
  • Kinase Binding
  • Metal Ion Binding
  • Protein C-Terminus Binding

Biological Processes:

  • Canonical Glycolysis
  • Fructose 6-Phosphate Metabolic Process
  • Glucose Homeostasis
  • Glycogen Catabolic Process
  • Glycolysis From Storage Polysaccharide Through Glucose-1-Phosphate
  • Glycolytic Process
  • Muscle Cell Cellular Homeostasis
  • Positive Regulation Of Insulin Secretion
  • Protein Oligomerization
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| ATP-PFK| muscle phosphofructokinase| PFK| phosphofructokinase 1| 6-phosphofructo-1-kinase| 6-phosphofructokinase, muscle type| 6-phosphofructokinase type A| AS27_13394| ATP-dependent 6-phosphofructokinase, muscle type| CB1_000322004| D623_10022125| EGK_03573| GSD7| H920_11342| MDA_GLEAN10022495| M-PFK| muscle 6-phosphofructokinase| muscle type phosphofructokinase| N302_08690| N303_05513| N308_00219| N310_13140| PAL_GLEAN10010016| PANDA_009078| PFK1| PFK-1| Pfk4| Pfk-4| Pfka| PFK-A| Pfk-M| Pfkx| PFMK| phosphofructo-1-kinase isozyme A| phosphofructokinase| phosphofructokinase-1 A isozyme| phosphofructokinase 4| phosphofructokinase-A| phosphofructokinase-M| phosphofructokinase-M (connecting peptide)| phosphofructokinase M variant 3/4| phosphofructokinase, polypeptide X| Phosphohexokinase| PPP1R122| protein phosphatase 1, regulatory subunit 122| TREES_T100018816| UY3_05843| Y1Q_029873| Y956_15942| pfkm

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