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  3. PFKFB3

PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3)

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The Function of PFKFB3

Synthesis and degradation of fructose 2,6-bisphosphate.

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Protein names

Recommended name:

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

Alternative name(s):

6PF-2-K/Fru-2,6-P2ase 3
PFK/FBPase 3
6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme
Renal carcinoma antigen NY-REN-56
iPFK-2

PFKFB3 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11257188 (PFKFB3) ??
  2. RS7077335 (PFKFB3) ??

Top Gene-Substance Interactions

PFKFB3 Interacts with These Diseases

Disease Score

Substances That Increase PFKFB3

Substances Interaction Organism Category

Substances That Decrease PFKFB3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Evi-1
  • PPAR-gamma1
  • PPAR-gamma2
  • RORalpha1
  • RORalpha2

Tissue specificity:

Ubiquitous.

Gene Pathways:

  • Metabolism
  • Disease
  • Fructose and mannose metabolism

Molecular Function:

  • 6-Phosphofructo-2-Kinase Activity
  • Atp Binding
  • Fructose-2,6-Bisphosphate 2-Phosphatase Activity

Biological Processes:

  • Brain Development
  • Canonical Glycolysis
  • Fructose 2,6-Bisphosphate Metabolic Process
  • Fructose Metabolic Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 6PF-2-K/Fru-2,6-P2ase 3| 6PF-2-K/Fru-2,6-P2ASE brain/placenta-type isozyme| 6PF-2-K/Fru-2,6-P2ASE brain-type isozyme| 6-phosphofructo-2-kinase| 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3-like| 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3| A306_15457| AS27_03781| AS28_04807| CB1_001581019| D623_10019413| f263| fructose-2,6-biphosphatase 3| fructose-6-phosphate,2-kinase/fructose-2, 6-bisphosphatase| H920_04095| inducible 6-phosphofructo-2-kinase| inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase| iPFK-2| IPFK2| M91_18187| M959_11303| MDA_GLEAN10014460| N300_00518| N301_07953| N302_08424| N303_10779| N305_12022| N306_04814| N307_09323| N308_13509| N309_04584| N310_03528| N311_06318| N312_07049| N320_07620| N321_12758| N322_04840| N324_11026| N325_06389| N327_07662| N328_05072| N329_01796| N330_06614| N331_12798| N332_01747| N333_01999| N335_07688| N336_01824| N339_04199| N340_06071| N341_07361| PAL_GLEAN10015754| PANDA_009136| PFK2| PFK/FBPase 3| RB2K| renal carcinoma antigen NY-REN-56| TREES_T100011938| uPFK-2| UY3_03947| Y1Q_029030| Y956_06217| Z169_05853| pfkfb3

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