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  3. PENK

PENK (Proenkephalin)

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The Function of PENK

Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum.

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Protein names

Recommended name:

Proenkephalin-A [Cleaved into: Synenkephalin; Met-enkephalin

Short name:

OGF

Alternative name(s):

Opioid growth factor
114-133
143-183
237-258

PENK SNPs

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  1. RS2609997 (PENK) ??

Top Gene-Substance Interactions

PENK Interacts with These Diseases

Disease Score

Substances That Increase PENK

Substances Interaction Organism Category

Substances That Decrease PENK

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • GR
  • GR-alpha
  • GR-beta
  • p53
  • AP-1
  • c-Jun
  • NF-kappaB1
  • c-Fos

Gene Pathways:

  • Signal Transduction

Molecular Function:

  • Neuropeptide Hormone Activity
  • Opioid Receptor Binding

Biological Processes:

  • Aggressive Behavior
  • Aging
  • Behavioral Fear Response
  • Cellular Response To Camp
  • Cellular Response To Oxidative Stress
  • Cellular Response To Transforming Growth Factor Beta Stimulus
  • Cellular Response To Virus
  • Cellular Response To Vitamin D
  • Chemical Synaptic Transmission
  • General Adaptation Syndrome, Behavioral Process
  • Glial Cell Proliferation
  • Locomotory Exploration Behavior
  • Neuropeptide Signaling Pathway
  • Osteoblast Differentiation
  • Positive Regulation Of Behavioral Fear Response
  • Response To Calcium Ion
  • Response To Epinephrine
  • Response To Estradiol
  • Response To Ethanol
  • Response To Hypoxia
  • Response To Lipopolysaccharide
  • Response To Morphine
  • Response To Nicotine
  • Response To Radiation
  • Response To Toxic Substance
  • Sensory Perception
  • Sensory Perception Of Pain
  • Signal Transduction
  • Startle Response
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| PE| AS27_01756| AS28_15137| CB1_000844002| D623_10024660| EGK_18970| ENK| enkephalin| enkephalin A| GW7_13950| H920_18134| I79_021680| MDA_GLEAN10024571| N300_10736| N301_15359| N302_13377| N303_03920| N305_09216| N306_12421| N307_01920| N308_01222| N309_14740| N311_10713| N320_00794| N321_03166| N322_09815| N324_10470| N325_04822| N326_00497| N327_13589| N328_01530| N329_10134| N330_04377| N331_11914| N332_02173| N333_08394| N334_11365| N335_03732| N336_10143| N339_08895| N340_13187| N341_00511| PAL_GLEAN10019265| PANDA_006831| Penk1| Penk2| PENK-A| Penk-rs| peptide F| PPA| PPENK| preproenkephalin| preproenkephalin 1| preproenkephalin 1-like| preproenkephalin 2| preproenkephalin, related sequence| proenkephalin 1| proenkephalin 2| Proenkephalin A| Proenkephalin-A| proenkephalin-A-like| proenkephalin-A-like protein| proenkephalin-A preproprotein| proenkephalin related sequence| putative preproenkephalin 1| spermatogenic-specific proenkephalin| TREES_T100010512| UY3_02005| Y1Q_002641| Y956_15581| Z169_08361| penk

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