The Function of PENK
Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum.
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Protein names
Recommended name:
Proenkephalin-A [Cleaved into: Synenkephalin; Met-enkephalinShort name:
OGFAlternative name(s):
Opioid growth factor114-133
143-183
237-258
- RS2609997 (PENK) ??
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Top Gene-Substance Interactions
PENK Interacts with These Diseases
| Disease | Score |
Substances That Increase PENK
| Substances | Interaction | Organism | Category |
Substances That Decrease PENK
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
Biological Processes:
- Aggressive Behavior
- Aging
- Behavioral Fear Response
- Cellular Response To Camp
- Cellular Response To Oxidative Stress
- Cellular Response To Transforming Growth Factor Beta Stimulus
- Cellular Response To Virus
- Cellular Response To Vitamin D
- Chemical Synaptic Transmission
- General Adaptation Syndrome, Behavioral Process
- Glial Cell Proliferation
- Locomotory Exploration Behavior
- Neuropeptide Signaling Pathway
- Osteoblast Differentiation
- Positive Regulation Of Behavioral Fear Response
- Response To Calcium Ion
- Response To Epinephrine
- Response To Estradiol
- Response To Ethanol
- Response To Hypoxia
- Response To Lipopolysaccharide
- Response To Morphine
- Response To Nicotine
- Response To Radiation
- Response To Toxic Substance
- Sensory Perception
- Sensory Perception Of Pain
- Signal Transduction
- Startle Response