The Function of PELI1
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation.
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Protein names
Recommended name:
E3 ubiquitin-protein ligase pellino homolog 1Alternative name(s):
Pellino-1Pellino-related intracellular-signaling molecule
- RS6733160 (PELI1) ??
- RS7604693 (PELI1) ??
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Top Gene-Substance Interactions
PELI1 Interacts with These Diseases
| Disease | Score |
Substances That Increase PELI1
| Substances | Interaction | Organism | Category |
Substances That Decrease PELI1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
Biological Processes:
- Negative Regulation Of Nf-Kappab Transcription Factor Activity
- Negative Regulation Of T Cell Proliferation
- Positive Regulation Of B Cell Proliferation
- Positive Regulation Of Cytokine Production
- Positive Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
- Positive Regulation Of Protein Ubiquitination
- Positive Regulation Of Toll-Like Receptor 3 Signaling Pathway
- Positive Regulation Of Toll-Like Receptor 4 Signaling Pathway
- Protein K48-Linked Ubiquitination
- Response To Dsrna
- Response To Lipopolysaccharide
- Toll Signaling Pathway