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  3. PELI1

PELI1 (Pellino E3 ubiquitin protein ligase 1)

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The Function of PELI1

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation.

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Protein names

Recommended name:

E3 ubiquitin-protein ligase pellino homolog 1

Alternative name(s):

Pellino-1
Pellino-related intracellular-signaling molecule

PELI1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS6733160 (PELI1) ??
  2. RS7604693 (PELI1) ??

Top Gene-Substance Interactions

PELI1 Interacts with These Diseases

Disease Score

Substances That Increase PELI1

Substances Interaction Organism Category

Substances That Decrease PELI1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Pbx1a
  • GATA-1
  • E4BP4

Gene Pathways:

  • Immune System

Molecular Function:

  • Ligase Activity
  • Ubiquitin-Ubiquitin Ligase Activity

Biological Processes:

  • Negative Regulation Of Nf-Kappab Transcription Factor Activity
  • Negative Regulation Of T Cell Proliferation
  • Positive Regulation Of B Cell Proliferation
  • Positive Regulation Of Cytokine Production
  • Positive Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
  • Positive Regulation Of Protein Ubiquitination
  • Positive Regulation Of Toll-Like Receptor 3 Signaling Pathway
  • Positive Regulation Of Toll-Like Receptor 4 Signaling Pathway
  • Protein K48-Linked Ubiquitination
  • Response To Dsrna
  • Response To Lipopolysaccharide
  • Toll Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_02262| AS27_12733| AS28_02297| CB1_000394031| D11Ertd676e| E3 ubiquitin-protein ligase pellino 1| E3 ubiquitin-protein ligase pellino homolog 1| E3 ubiquitin-protein ligase pellino homolog 2| EGK_05378| GW7_04887| H920_17514| M91_21506| M959_10779| N300_05338| N301_14912| N302_08618| N303_01257| N305_03642| N306_01359| N307_07898| N308_08528| N309_07239| N310_07266| N311_05073| N312_05290| N320_11055| N322_12993| N324_02741| N325_11120| N326_10450| N327_12527| N328_07766| N329_00565| N330_02564| N331_04525| N332_07710| N333_03193| N334_14102| N335_08779| N336_07561| N339_02603| N341_04702| PAL_GLEAN10021204| PANDA_015948| pellino1| pellino 1| pellino-1| pellino homolog 1| pellino-like protein 1| pellino protein| pellino-related intracellular-signaling molecule| protein pellino homolog 1| Protein pellino-like 1| protein pellino-like 1-like protein| Protein pellino like protein 1| Protein pellino-like protein 1| TREES_T100000709| UY3_09937| xpellino1| Y1Q_030237| Y956_07293| Z169_08734| peli1

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