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  3. PDZRN3

PDZRN3 (PDZ domain containing ring finger 3)

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The Function of PDZRN3

E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation.

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Protein names

Recommended name:

E3 ubiquitin-protein ligase PDZRN3

Alternative name(s):

Ligand of Numb protein X 3
PDZ domain-containing RING finger protein 3
Semaphorin cytoplasmic domain-associated protein 3
Protein SEMACAP3

PDZRN3 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11128347 (PDZRN3) ??
  2. RS4557101 (PDZRN3) ??

Top Gene-Substance Interactions

Substances That Increase PDZRN3

Substances Interaction Organism Category

Substances That Decrease PDZRN3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Brachyury
  • E4BP4
  • Bach2
  • Ik-1

Tissue specificity:

Widely expressed, including in the heart, skeletal muscle and liver and, at lower levels, in the brain, colon, small intestine, placenta and lung. Down-regulated in ovarian serous papillary tumors.

Molecular Function:

  • Ligase Activity
  • Ubiquitin Protein Ligase Activity
  • Ubiquitin-Protein Transferase Activity
  • Zinc Ion Binding

Biological Processes:

  • Neuromuscular Junction Development
  • Protein Ubiquitination
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AL023082| Anapl_16097| AS27_07201| AS28_08958| CB1_000195010| e3 ubiquitin-protein ligase PDZRN3| EH28_24810| GW7_10740| H920_07800| I79_000356| ligand of Numb protein X 3| likely ortholog of mouse semaF cytoplasmic domain associated protein 3| LNX3| M91_07399| M959_05628| N300_07205| N301_08140| N302_15828| N303_08613| N305_08511| N306_12822| N307_11737| N308_15508| N309_10801| N310_01498| N311_12826| N312_05897| N320_06863| N325_08437| N328_01143| N329_08364| N330_14394| N331_12855| N335_11436| N341_02703| PANDA_002620| PDZ domain containing 4| PDZ domain containing RING finger 3A| PDZ domain-containing RING finger protein 3| SEMACAP3| semaphorin cytoplasmic domain-associated protein 3| semaphorin cytoplasmic domain-associated protein 3A| SEMCAP3| TREES_T100020400| UY3_14063| Y1Q_000399| Y956_14426| Z169_04892| pdzrn3

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