The Function of PDZRN3
E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation.
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Protein names
Recommended name:
E3 ubiquitin-protein ligase PDZRN3Alternative name(s):
Ligand of Numb protein X 3PDZ domain-containing RING finger protein 3
Semaphorin cytoplasmic domain-associated protein 3
Protein SEMACAP3
- RS11128347 (PDZRN3) ??
- RS4557101 (PDZRN3) ??
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Top Gene-Substance Interactions
Substances That Increase PDZRN3
| Substances | Interaction | Organism | Category |
Substances That Decrease PDZRN3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Widely expressed, including in the heart, skeletal muscle and liver and, at lower levels, in the brain, colon, small intestine, placenta and lung. Down-regulated in ovarian serous papillary tumors.
Molecular Function:
- Ligase Activity
- Ubiquitin Protein Ligase Activity
- Ubiquitin-Protein Transferase Activity
- Zinc Ion Binding