The Function of PDX1
Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.
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Protein names
Recommended name:
Pyruvate dehydrogenase protein X component, mitochondrialShort name:
E3BPAlternative name(s):
Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complexE3-binding protein
Lipoyl-containing pyruvate dehydrogenase complex component X
proX
Top Gene-Substance Interactions
PDX1 Interacts with These Diseases
| Disease | Score |
Substances That Increase PDX1
| Substances | Interaction | Organism | Category |
Substances That Decrease PDX1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells).
Gene Pathways:
Molecular Function:
- Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
- Core Promoter Sequence-Specific Dna Binding
- Chromatin Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Factor Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
- Transferase Activity, Transferring Acyl Groups
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Liver Development
- Type B Pancreatic Cell Differentiation
- Glucose Metabolic Process
- Pyruvate Metabolic Process
- Generation Of Precursor Metabolites And Energy
- Transcription From Rna Polymerase Ii Promoter
- Smoothened Signaling Pathway
- Nitric Oxide Mediated Signal Transduction
- Central Nervous System Development
- Positive Regulation Of Cell Proliferation
- Negative Regulation Of Cell Proliferation
- Response To Wounding
- Animal Organ Morphogenesis
- Response To Iron(Ii) Ion
- Response To Chlorate
- Animal Organ Senescence
- Regulation Of Acetyl-Coa Biosynthetic Process From Pyruvate
- Positive Regulation Of Cell Death
- Morphogenesis Of Embryonic Epithelium
- Insulin Secretion
- Exocrine Pancreas Development
- Animal Organ Regeneration
- Response To Vitamin
- Response To Cytokine
- Response To Nicotine
- Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
- Glucose Homeostasis
- Response To Leucine
- Positive Regulation Of Dna Binding
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Glyoxylate Metabolic Process
- Digestive Tract Development
- Stem Cell Differentiation
- Response To Glucocorticoid
- Detection Of Glucose
- Transdifferentiation
- Mitochondrial Acetyl-Coa Biosynthetic Process From Pyruvate
- Response To Fatty Acid
- Negative Regulation Of Endoplasmic Reticulum Stress-Induced Intrinsic Apoptotic Signaling Pathway
- Negative Regulation Of Type B Pancreatic Cell Apoptotic Process