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  3. PDX1

PDX1 (Pancreatic and duodenal homeobox 1)

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The Function of PDX1

Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.

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Protein names

Recommended name:

Pyruvate dehydrogenase protein X component, mitochondrial

Short name:

E3BP

Alternative name(s):

Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex
E3-binding protein
Lipoyl-containing pyruvate dehydrogenase complex component X
proX

Top Gene-Substance Interactions

PDX1 Interacts with These Diseases

Disease Score

Substances That Increase PDX1

Substances Interaction Organism Category

Substances That Decrease PDX1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • RORalpha1
  • Egr-1
  • C/EBPbeta
  • E47
  • p300

Tissue specificity:

Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells).

Gene Pathways:

  • Type II diabetes mellitus
  • Maturity onset diabetes of the young
  • Regulation of Beta-Cell Development

Molecular Function:

  • Chromatin Binding
  • Core Promoter Sequence-Specific Dna Binding
  • Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
  • Transcription Factor Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
  • Transcription Factor Activity, Sequence-Specific Dna Binding
  • Transferase Activity, Transferring Acyl Groups

Biological Processes:

  • Animal Organ Morphogenesis
  • Animal Organ Regeneration
  • Animal Organ Senescence
  • Central Nervous System Development
  • Detection Of Glucose
  • Digestive Tract Development
  • Exocrine Pancreas Development
  • Generation Of Precursor Metabolites And Energy
  • Glucose Homeostasis
  • Glucose Metabolic Process
  • Insulin Secretion
  • Liver Development
  • Morphogenesis Of Embryonic Epithelium
  • Negative Regulation Of Cell Proliferation
  • Negative Regulation Of Endoplasmic Reticulum Stress-Induced Intrinsic Apoptotic Signaling Pathway
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
  • Nitric Oxide Mediated Signal Transduction
  • Positive Regulation Of Cell Death
  • Positive Regulation Of Cell Proliferation
  • Positive Regulation Of Dna Binding
  • Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Response To Chlorate
  • Response To Cytokine
  • Response To Fatty Acid
  • Response To Glucocorticoid
  • Response To Iron(Ii) Ion
  • Response To Leucine
  • Response To Nicotine
  • Response To Vitamin
  • Response To Wounding
  • Smoothened Signaling Pathway
  • Stem Cell Differentiation
  • Transcription From Rna Polymerase Ii Promoter
  • Transdifferentiation
  • Type B Pancreatic Cell Differentiation
  • Glyoxylate Metabolic Process
  • Mitochondrial Acetyl-Coa Biosynthetic Process From Pyruvate
  • Pyruvate Metabolic Process
  • Regulation Of Acetyl-Coa Biosynthetic Process From Pyruvate
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

A306_11821| AS28_02397| CB1_001907062| glucose-sensitive factor| GSF| GW7_12522| homeodomain protein PDX-1| Homeodomain protein PDX1| Idx1| IDX-1| Insulin promoter factor 1| insulin promoter factor 1, homeodomain transcription factor| insulin promotor factor 1| insulin upstream factor 1| IPF1| IPF-1| islet/duodenum homeobox 1| islet/duodenum homeobox-1| IUF1| IUF-1| M91_04432| MODY4| PAGEN1| PAL_GLEAN10006831| Pancreas/duodenum homeobox protein 1| pancreas/duodenum homeobox protein 1-like| pancreas/duodenum homeobox protein 1-like protein| pancreatic and duodenal homeobox gene 1| pancreatic and duodenal homeobox protein| pancreatic and duodenum homeobox 1| pancreatic-duodenal homeobox factor 1| pancreatic duodenal homeobox gene 1| PANDA_016115| PDX| PDX-1| somatostatin transactivating factor 1| somatostatin-transactivating factor 1| somatostatin transcription factor 1| Stf1| STF-1| TREES_T100016465| UY3_05212| XlHbox8| XlHbox-8| Y1Q_010940| pdx1

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