Summary of PDLIM5
This gene encodes a protein that connects protein kinases to the Z-disk in striated muscles. It also restrains postsynaptic growth of excitatory synapses (R).
The Function of PDLIM5
May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses.
Protein names
Recommended name:
PDZ and LIM domain protein 5Alternative name(s):
Enigma homologEnigma-like PDZ and LIM domains protein
- RS10027628 (PDLIM5) ??
- RS12500426 (PDLIM5) ??
- RS13107595 (PDLIM5) ??
- RS13133845 (PDLIM5) ??
- RS17021918 (PDLIM5) ??
- RS17022027 (PDLIM5) ??
- RS17336353 (PDLIM5) ??
- RS2433322 (PDLIM5) ??
- RS2452591 (PDLIM5) ??
- RS2452600 (PDLIM5) ??
- RS4699587 (PDLIM5) ??
- RS7690296 (PDLIM5) ??
- RS9757252 (PDLIM5) ??
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Top Gene-Substance Interactions
PDLIM5 Interacts with These Diseases
| Disease | Score |
Substances That Increase PDLIM5
| Substances | Interaction | Organism | Category |
Substances That Decrease PDLIM5
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Heart and skeletal muscle specific. Expression is commonly increased in the brain of patients with bipolar disorder, schizophrenia, and major depression.
Molecular Function:
- Actin Binding
- Protein Kinase C Binding
- Zinc Ion Binding
- Actinin Binding
- Cadherin Binding Involved In Cell-Cell Adhesion
Biological Processes:
- Regulation Of Synapse Assembly
- Regulation Of Dendritic Spine Morphogenesis
- Cell Growth Involved In Cardiac Muscle Cell Development