• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. PDLIM5

PDLIM5 (PDZ and LIM domain 5)

Loading...

Summary of PDLIM5

This gene encodes a protein that connects protein kinases to the Z-disk in striated muscles. It also restrains postsynaptic growth of excitatory synapses (R).

0 users want this gene increased, 0 users want it decreased

The Function of PDLIM5

May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses.

Protein names

Recommended name:

PDZ and LIM domain protein 5

Alternative name(s):

Enigma homolog
Enigma-like PDZ and LIM domains protein

PDLIM5 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10027628 (PDLIM5) ??
  2. RS12500426 (PDLIM5) ??
  3. RS13107595 (PDLIM5) ??
  4. RS13133845 (PDLIM5) ??
  5. RS17021918 (PDLIM5) ??
  6. RS17022027 (PDLIM5) ??
  7. RS17336353 (PDLIM5) ??
  8. RS2433322 (PDLIM5) ??
  9. RS2452591 (PDLIM5) ??
  10. RS2452600 (PDLIM5) ??
  11. RS4699587 (PDLIM5) ??
  12. RS7690296 (PDLIM5) ??
  13. RS9757252 (PDLIM5) ??

Top Gene-Substance Interactions

PDLIM5 Interacts with These Diseases

Disease Score

Substances That Increase PDLIM5

Substances Interaction Organism Category

Substances That Decrease PDLIM5

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CUTL1
  • Lmo2
  • GATA-6

Tissue specificity:

Heart and skeletal muscle specific. Expression is commonly increased in the brain of patients with bipolar disorder, schizophrenia, and major depression.

Molecular Function:

  • Actin Binding
  • Actinin Binding
  • Cadherin Binding Involved In Cell-Cell Adhesion
  • Protein Kinase C Binding
  • Zinc Ion Binding

Biological Processes:

  • Cell Growth Involved In Cardiac Muscle Cell Development
  • Regulation Of Dendritic Spine Morphogenesis
  • Regulation Of Synapse Assembly
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| enigma homolog| C87059| CB1_001710008| D623_10005265| ENH| enh1| Enh2| Enh3| enigma-like LIM domain protein| enigma-like PDZ and LIM domains protein| GW7_03233| H920_13643| I79_024263| L9| LIM| M959_05084| MDA_GLEAN10011019| N301_10094| N303_06771| N305_08025| N306_02859| N307_12136| N308_06212| N311_13053| N312_12514| N320_02134| N321_08547| N322_12379| N324_00726| N325_05318| N327_04212| N329_12319| N330_03228| N331_05342| N339_09420| N340_14842| PAL_GLEAN10010934| PANDA_003307| PDZ and LIM domain 5b| PDZ and LIM domain 5 isoform ENH2 isoform 4-like protein| PDZ and LIM domain protein 5| TREES_T100009481| UY3_10063| Y1Q_004177| Y956_00973| Z169_14884| pdlim5

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved