The Function of PDGFD
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix.
Protein names
Recommended name:
Platelet-derived growth factor DShort name:
PDGF-DAlternative name(s):
Iris-expressed growth factorSpinal cord-derived growth factor B
SCDGF-B
PDGFD latent form
PDGFD receptor-binding form
- RS10895547 (PDGFD) ??
- RS7930114 (PDGFD) ??
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Top Gene-Substance Interactions
PDGFD Interacts with These Diseases
| Disease | Score |
Substances That Increase PDGFD
| Substances | Interaction | Organism | Category |
Substances That Decrease PDGFD
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed at high levels in the heart, pancreas, adrenal gland and ovary and at low levels in placenta, liver, kidney, prostate, testis, small intestine, spleen and colon. In the kidney, expressed by the visceral epithelial cells of the glomeruli. A widespread expression is also seen in the medial smooth muscle cells of arteries and arterioles, as well as in smooth muscle cells of vasa rectae in the medullary area. Expressed in the adventitial connective tissue surrounding the suprarenal artery. In chronic obstructive nephropathy, a persistent expression is seen in glomerular visceral epithelial cells and vascular smooth muscle cells, as well as de novo expression by periglomerular interstitial cells and by some neointimal cells of atherosclerotic vessels. Expression in normal prostate is seen preferentially in the mesenchyme of the gland while expression is increased and more profuse in prostate carcinoma. Expressed in many ovarian, lung, renal and brain cancer-derived cell lines.
Gene Pathways:
Developmental stage:
Not detectable in the earliest stages of glomerulogenesis, and not detected in the metanephric blastema or surrounding cortical interstitial cells. In later stages of glomerulogenesis, localized to epithelial cells transitioning from the early developing nephrons of the comma- and S-shaped stages to the visceral epithelial cells of differentiated glomeruli. In the developing pelvis, expressed at the basement membrane of immature collecting ducts and by presumptive fibroblastic cells in the interstitium.
Molecular Function:
Biological Processes:
- Blood Coagulation
- Cellular Response To Amino Acid Stimulus
- Cellular Response To Hydrogen Peroxide
- Cellular Response To Platelet-Derived Growth Factor Stimulus
- Cellular Response To Transforming Growth Factor Beta Stimulus
- Multicellular Organism Development
- Platelet-Derived Growth Factor Receptor Signaling Pathway
- Positive Regulation Of Cell Division
- Positive Regulation Of Cell Migration
- Positive Regulation Of Cell Proliferation
- Positive Regulation Of Erk1 And Erk2 Cascade
- Positive Regulation Of Fibroblast Proliferation
- Positive Regulation Of Glomerular Mesangial Cell Proliferation
- Positive Regulation Of Map Kinase Activity
- Positive Regulation Of Monocyte Extravasation
- Positive Regulation Of Phosphatidylinositol 3-Kinase Signaling
- Positive Regulation Of Protein Autophosphorylation
- Positive Regulation Of Smooth Muscle Cell Chemotaxis
- Positive Regulation Of Smooth Muscle Cell Proliferation
- Regulation Of Peptidyl-Tyrosine Phosphorylation