The Function of PDGFC
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.
Protein names
Recommended name:
Platelet-derived growth factor CShort name:
SCDGFAlternative name(s):
PDGF-CFallotein
Spinal cord-derived growth factor
VEGF-E
PDGFC latent form
PDGFC receptor-binding form
- RS1425486 (PDGFC) ??
- RS4691380 (PDGFC) ??
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Top Gene-Substance Interactions
PDGFC Interacts with These Diseases
| Disease | Score |
Substances That Increase PDGFC
| Substances | Interaction | Organism | Category |
Substances That Decrease PDGFC
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in the fallopian tube, vascular smooth muscle cells in kidney, breast and colon and in visceral smooth muscle of the gastrointestinal tract. Highly expressed in retinal pigment epithelia. Expressed in medulloblastoma. In the kidney, constitutively expressed in parietal epithelial cells of Bowman's capsule, tubular epithelial cells and in arterial endothelial cells (at protein level). Highly expressed in the platelets, prostate, testis and uterus. Higher expression is observed in uterine leiomyomata. Weaker expression in the spleen, thymus, heart, pancreas, liver, ovary cells and small intestine, and negligible expression in the colon and peripheral blood leukocytes.
Gene Pathways:
Induction:
Up-regulated by EWS-FLI1 chimeric transcription factor in tumor derived cells. Up-regulated in podocytes and interstitial cells after injury/activation of these cells. FGF2 activates PDGFC transcription via EGR1. Up-regulated by TGFB1 in concert with FGF2.
Developmental stage:
In the fetal kidney, detected in the developing mesangium, ureteric bud epithelium and the undifferentiated mesenchyme (at protein level).
Molecular Function:
Biological Processes:
- Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity
- Animal Organ Morphogenesis
- Blood Coagulation
- Bone Development
- Cellular Response To Amino Acid Stimulus
- Central Nervous System Development
- Digestive Tract Development
- Embryo Development
- Platelet-Derived Growth Factor Receptor Signaling Pathway
- Positive Regulation Of Cell Division
- Positive Regulation Of Cell Migration
- Positive Regulation Of Dna Replication
- Positive Regulation Of Erk1 And Erk2 Cascade
- Positive Regulation Of Fibroblast Proliferation
- Positive Regulation Of Map Kinase Activity
- Positive Regulation Of Phosphatidylinositol 3-Kinase Signaling
- Positive Regulation Of Protein Autophosphorylation
- Regulation Of Peptidyl-Tyrosine Phosphorylation