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  3. PBX1

PBX1 (PBX homeobox 1)

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The Function of PBX1

Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Probably in complex with MEIS2, is involved in transcriptional regulation by KLF4. Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B. Together with NKX2-5, it is required for spleen development through a mechanism that involves CDKN2B repression.

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Protein names

Recommended name:

Pre-B-cell leukemia transcription factor 1

Alternative name(s):

Homeobox protein PBX1
Homeobox protein PRL

PBX1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1387389 (PBX1) ??
  2. RS6670655 (PBX1) ??

Top Gene-Substance Interactions

Substances That Increase PBX1

Substances Interaction Organism Category

Substances That Decrease PBX1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • AP-1
  • c-Jun
  • c-Fos
  • AML1a

Tissue specificity:

Expressed in all tissues except in cells of the B and T lineage.

Molecular Function:

  • Dna Binding
  • Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
  • Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
  • Transcription Factor Activity, Sequence-Specific Dna Binding
  • Transcription Factor Binding

Biological Processes:

  • Adrenal Gland Development
  • Anterior/Posterior Pattern Specification
  • Branching Involved In Ureteric Bud Morphogenesis
  • Embryonic Hemopoiesis
  • Embryonic Limb Morphogenesis
  • Embryonic Skeletal System Development
  • Negative Regulation Of Neuron Differentiation
  • Negative Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
  • Positive Regulation Of Cell Proliferation
  • Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
  • Proximal/Distal Pattern Formation
  • Regulation Of Ossification
  • Sex Differentiation
  • Somatic Stem Cell Population Maintenance
  • Spleen Development
  • Steroid Biosynthetic Process
  • Thymus Development
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_13628| Anapl_14919| AS27_15734| AS28_09945| CB1_000237013| H920_09460| homeobox protein PBX1| homeobox protein PRL| I79_011119| M959_08670| N300_11957| N301_09676| N302_00501| N303_07920| N305_07597| N306_01383| N308_02222| N328_00809| PAL_GLEAN10017892| PANDA_002081| Pbx-1| PBX1A| pbx1b| pre B cell leukemia homeobox 1| pre-B-cell leukemia homeobox 1| pre B-cell leukemia transcription factor 1| Pre-B-cell leukemia transcription factor 1| TREES_T100015731| Xpbx1| Xpbx1b| Y1Q_024538| Y956_03434| Z169_13448| pbx1

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