The Function of PBX1
Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Probably in complex with MEIS2, is involved in transcriptional regulation by KLF4. Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B. Together with NKX2-5, it is required for spleen development through a mechanism that involves CDKN2B repression.
Protein names
Recommended name:
Pre-B-cell leukemia transcription factor 1Alternative name(s):
Homeobox protein PBX1Homeobox protein PRL
- RS1387389 (PBX1) ??
- RS6670655 (PBX1) ??
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Top Gene-Substance Interactions
Substances That Increase PBX1
| Substances | Interaction | Organism | Category |
Substances That Decrease PBX1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in all tissues except in cells of the B and T lineage.
Molecular Function:
- Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Dna Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Factor Binding
Biological Processes:
- Branching Involved In Ureteric Bud Morphogenesis
- Steroid Biosynthetic Process
- Sex Differentiation
- Positive Regulation Of Cell Proliferation
- Anterior/Posterior Pattern Specification
- Proximal/Distal Pattern Formation
- Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
- Regulation Of Ossification
- Adrenal Gland Development
- Embryonic Limb Morphogenesis
- Somatic Stem Cell Population Maintenance
- Embryonic Hemopoiesis
- Negative Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
- Negative Regulation Of Neuron Differentiation
- Spleen Development
- Thymus Development
- Embryonic Skeletal System Development