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  3. PAX2

PAX2 (Paired box 2)

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The Function of PAX2

Transcription factor that may have a role in kidney cell differentiation (PubMed:24676634). Has a critical role in the development of the urogenital tract, the eyes, and the CNS.

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Protein names

Recommended name:

Paired box protein Pax-2

PAX2 SNPs

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  1. RS4509693 (PAX2) ??

Top Gene-Substance Interactions

PAX2 Interacts with These Diseases

Disease Score

Substances That Increase PAX2

Substances Interaction Organism Category

Substances That Decrease PAX2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Pax-6
  • Pax-2
  • Pax-5
  • FOXC1
  • NF-kappaB2
  • HFH-1

Tissue specificity:

Expressed in primitive cells of the kidney, ureter, eye, ear and central nervous system.

Developmental stage:

Mainly in fetal kidney and juvenile nephrogenic rests.

Molecular Function:

  • Core Promoter Proximal Region Sequence-Specific Dna Binding
  • Dna Binding
  • Superoxide-Generating Nadph Oxidase Activity
  • Transcription Factor Binding
  • Transcription Regulatory Region Dna Binding

Biological Processes:

  • Aging
  • Axonogenesis
  • Brain Morphogenesis
  • Branching Involved In Ureteric Bud Morphogenesis
  • Camera-Type Eye Development
  • Cell Fate Determination
  • Cellular Response To Epidermal Growth Factor Stimulus
  • Cellular Response To Glucose Stimulus
  • Cellular Response To Hydrogen Peroxide
  • Cellular Response To Retinoic Acid
  • Cochlea Development
  • Cochlea Morphogenesis
  • Glial Cell Differentiation
  • Inner Ear Morphogenesis
  • Mesenchymal To Epithelial Transition
  • Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis
  • Mesodermal Cell Fate Specification
  • Mesonephros Development
  • Metanephric Collecting Duct Development
  • Metanephric Distal Convoluted Tubule Development
  • Metanephric Epithelium Development
  • Metanephric Mesenchymal Cell Differentiation
  • Metanephric Mesenchyme Development
  • Metanephric Nephron Tubule Formation
  • Negative Regulation Of Apoptotic Process
  • Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development
  • Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development
  • Negative Regulation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
  • Negative Regulation Of Cytolysis
  • Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis
  • Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development
  • Negative Regulation Of Programmed Cell Death
  • Negative Regulation Of Reactive Oxygen Species Metabolic Process
  • Negative Regulation Of Transcription, Dna-Templated
  • Nephric Duct Formation
  • Neural Tube Closure
  • Optic Chiasma Development
  • Optic Cup Morphogenesis Involved In Camera-Type Eye Development
  • Optic Nerve Development
  • Optic Nerve Morphogenesis
  • Optic Nerve Structural Organization
  • Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis
  • Positive Regulation Of Epithelial Cell Proliferation
  • Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis
  • Positive Regulation Of Metanephric Dct Cell Differentiation
  • Positive Regulation Of Metanephric Glomerulus Development
  • Positive Regulation Of Optic Nerve Formation
  • Positive Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Pronephric Field Specification
  • Pronephros Development
  • Protein Kinase B Signaling
  • Reactive Oxygen Species Metabolic Process
  • Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation
  • Regulation Of Metanephros Size
  • Response To Nutrient Levels
  • Retinal Pigment Epithelium Development
  • Stem Cell Differentiation
  • Transcription, Dna-Templated
  • Transcription From Rna Polymerase Ii Promoter
  • Ureter Development
  • Ureter Maturation
  • Urogenital System Development
  • Vestibulocochlear Nerve Formation
  • Visual Perception
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_12455| AS27_02555| AS28_05926| CB1_000642018| FSGS7| I79_021155| M91_06681| M959_03577| MDA_GLEAN10023392| N300_11774| N301_10695| N302_13439| N303_09239| N306_12212| N307_06093| N308_00285| N309_00807| N310_01245| N324_05985| Opdc| optic disc coloboma| paired-box containing protein Pax-2| paired box gene 2| paired box homeotic gene 2| paired box protein 2| paired box protein 2a| paired box protein Pax-2| Paired box protein Pax-2a| Paired box protein Pax-2-A| paired box protein Pax-2-A-like| PAL_GLEAN10018267| PANDA_001742| PAPRS| pax-2| pax2a| pax2-a| pax2-b| TREES_T100012319| UY3_00943| XPax2| XPax-2| Y1Q_016442| Y956_09094| Z169_12763| pax2

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