The Function of PAX2
Transcription factor that may have a role in kidney cell differentiation (PubMed:24676634). Has a critical role in the development of the urogenital tract, the eyes, and the CNS.
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Protein names
Recommended name:
Paired box protein Pax-2- RS4509693 (PAX2) ??
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Top Gene-Substance Interactions
PAX2 Interacts with These Diseases
| Disease | Score |
Substances That Increase PAX2
| Substances | Interaction | Organism | Category |
Substances That Decrease PAX2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in primitive cells of the kidney, ureter, eye, ear and central nervous system.
Developmental stage:
Mainly in fetal kidney and juvenile nephrogenic rests.
Molecular Function:
- Core Promoter Proximal Region Sequence-Specific Dna Binding
- Dna Binding
- Transcription Factor Binding
- Superoxide-Generating Nadph Oxidase Activity
- Transcription Regulatory Region Dna Binding
Biological Processes:
- Urogenital System Development
- Branching Involved In Ureteric Bud Morphogenesis
- Cell Fate Determination
- Mesonephros Development
- Neural Tube Closure
- Optic Cup Morphogenesis Involved In Camera-Type Eye Development
- Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis
- Retinal Pigment Epithelium Development
- Transcription, Dna-Templated
- Transcription From Rna Polymerase Ii Promoter
- Axonogenesis
- Mesodermal Cell Fate Specification
- Aging
- Visual Perception
- Glial Cell Differentiation
- Optic Nerve Development
- Optic Nerve Morphogenesis
- Optic Nerve Structural Organization
- Vestibulocochlear Nerve Formation
- Response To Nutrient Levels
- Regulation Of Metanephros Size
- Ureter Maturation
- Pronephric Field Specification
- Inner Ear Morphogenesis
- Camera-Type Eye Development
- Negative Regulation Of Apoptotic Process
- Negative Regulation Of Programmed Cell Death
- Negative Regulation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
- Protein Kinase B Signaling
- Negative Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription, Dna-Templated
- Negative Regulation Of Cytolysis
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Pronephros Development
- Brain Morphogenesis
- Stem Cell Differentiation
- Positive Regulation Of Epithelial Cell Proliferation
- Mesenchymal To Epithelial Transition
- Optic Chiasma Development
- Cellular Response To Hydrogen Peroxide
- Cellular Response To Retinoic Acid
- Cellular Response To Glucose Stimulus
- Cellular Response To Epidermal Growth Factor Stimulus
- Metanephric Mesenchyme Development
- Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis
- Metanephric Mesenchymal Cell Differentiation
- Nephric Duct Formation
- Ureter Development
- Metanephric Collecting Duct Development
- Metanephric Epithelium Development
- Metanephric Distal Convoluted Tubule Development
- Metanephric Nephron Tubule Formation
- Positive Regulation Of Metanephric Glomerulus Development
- Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis
- Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation
- Reactive Oxygen Species Metabolic Process
- Cochlea Development
- Cochlea Morphogenesis
- Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis
- Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development
- Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development
- Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development
- Negative Regulation Of Reactive Oxygen Species Metabolic Process
- Positive Regulation Of Metanephric Dct Cell Differentiation
- Positive Regulation Of Optic Nerve Formation