The Function of PARK7
Protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteines, arginines and lysines residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) (PubMed:25416785). Plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease; functions probably related to its primary function (PubMed:17015834, PubMed:20304780, PubMed:18711745, PubMed:12796482, PubMed:19229105, PubMed:25416785). It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway (PubMed:12612053, PubMed:15502874, PubMed:14749723, PubMed:17015834, PubMed:21097510, PubMed:18711745). Its involvement in protein repair could also explain other unrelated functions. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death (PubMed:16390825). Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria (PubMed:19229105, PubMed:16632486). Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking (PubMed:18711745). Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells (PubMed:23847046). Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress (PubMed:18626009). Metal-binding protein able to bind copper as well as toxic mercury ions, enhances the cell protection mechanism against induced metal toxicity (PubMed:23792957).
Protein names
Recommended name:
Protein deglycase DJ-1Short name:
DJ-1Alternative name(s):
Oncogene DJ1Parkinson disease protein 7
- RS12727642 (PARK7) ??
- RS161802 (PARK7) ??
- RS35675666 (PARK7) ??
- RS3766606 (PARK7) ??
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Top Gene-Substance Interactions
PARK7 Interacts with These Diseases
| Disease | Score |
Substances That Increase PARK7
| Substances | Interaction | Organism | Category |
Substances That Decrease PARK7
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in pancreas, kidney, skeletal muscle, liver, testis and heart. Detected at slightly lower levels in placenta and brain (at protein level). Detected in astrocytes, Sertoli cells, spermatogonia, spermatids and spermatozoa.
Gene Pathways:
Induction:
By hydrogen peroxide and UV irradiation.
Caution:
Glyoxalase activity previously reported reflects in fact its deglycase activity (PubMed:22523093, PubMed:25416785).
Cofactor:
Does not require glutathione as a cofactor, however, glycated glutathione constitutes a PARK7 substrate.
Molecular Function:
- Transcription Coactivator Activity
- Mrna Binding
- Receptor Binding
- Copper Ion Binding
- Transcription Factor Binding
- Peptidase Activity
- Superoxide Dismutase Copper Chaperone Activity
- Oxidoreductase Activity, Acting On Peroxide As Acceptor
- Glyoxalase Iii Activity
- Enzyme Binding
- Kinase Binding
- Cytokine Binding
- Tyrosine 3-Monooxygenase Activator Activity
- L-Dopa Decarboxylase Activator Activity
- Protein Deglycase Activity
- Identical Protein Binding
- Protein Homodimerization Activity
- Small Protein Activating Enzyme Binding
- Ubiquitin-Like Protein Conjugating Enzyme Binding
- Mercury Ion Binding
- Androgen Receptor Binding
- Peroxiredoxin Activity
- Repressing Transcription Factor Binding
- Scaffold Protein Binding
- Cadherin Binding Involved In Cell-Cell Adhesion
- Cupric Ion Binding
- Cuprous Ion Binding
- Ubiquitin-Specific Protease Binding
- Glyoxalase (Glycolic Acid-Forming) Activity
Biological Processes:
- Negative Regulation Of Protein Phosphorylation
- Negative Regulation Of Protein Kinase Activity
- Protein Deglycosylation
- Autophagy
- Inflammatory Response
- Mitochondrion Organization
- Ras Protein Signal Transduction
- Single Fertilization
- Adult Locomotory Behavior
- Methylglyoxal Metabolic Process
- Detoxification Of Copper Ion
- Positive Regulation Of Gene Expression
- Negative Regulation Of Gene Expression
- Enzyme Active Site Formation Via L-Cysteine Sulfinic Acid
- Methylglyoxal Catabolic Process To D-Lactate Via S-Lactoyl-Glutathione
- Lactate Biosynthetic Process
- Protein Repair
- Negative Regulation Of Protein Ubiquitination
- Activation Of Protein Kinase B Activity
- Negative Regulation Of Proteasomal Ubiquitin-Dependent Protein Catabolic Process
- Positive Regulation Of Interleukin-8 Production
- Positive Regulation Of Peptidyl-Serine Phosphorylation
- Negative Regulation Of Protein Sumoylation
- Cellular Response To Oxidative Stress
- Cellular Response To Glyoxal
- Peptidyl-Cysteine Deglycation
- Peptidyl-Arginine Deglycation
- Peptidyl-Lysine Deglycation
- Protein Deglycation, Glyoxal Removal
- Protein Deglycation, Methylglyoxal Removal
- Glutathione Deglycation
- Hydrogen Peroxide Metabolic Process
- Negative Regulation Of Apoptotic Process
- Regulation Of Neuron Apoptotic Process
- Negative Regulation Of Neuron Apoptotic Process
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Glycolate Biosynthetic Process
- Negative Regulation Of Protein Export From Nucleus
- Regulation Of Inflammatory Response
- Detoxification Of Mercury Ion
- Protein Stabilization
- Positive Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
- Negative Regulation Of Ubiquitin-Protein Transferase Activity
- Dopamine Uptake Involved In Synaptic Transmission
- Regulation Of Mitochondrial Membrane Potential
- Positive Regulation Of Protein Kinase B Signaling
- Membrane Depolarization
- Membrane Hyperpolarization
- Negative Regulation Of Cell Death
- Regulation Of Androgen Receptor Signaling Pathway
- Cellular Response To Hydrogen Peroxide
- Positive Regulation Of Protein Homodimerization Activity
- Positive Regulation Of Protein Localization To Nucleus
- Negative Regulation Of Neuron Death
- Positive Regulation Of Superoxide Dismutase Activity
- Negative Regulation Of Protein Acetylation
- Positive Regulation Of Oxidative Stress-Induced Intrinsic Apoptotic Signaling Pathway
- Negative Regulation Of Endoplasmic Reticulum Stress-Induced Intrinsic Apoptotic Signaling Pathway
- Regulation Of Supramolecular Fiber Organization
- Positive Regulation Of Mitochondrial Electron Transport, Nadh To Ubiquinone
- Negative Regulation Of Death-Inducing Signaling Complex Assembly
- Negative Regulation Of Protein K48-Linked Deubiquitination
- Negative Regulation Of Trail-Activated Apoptotic Signaling Pathway
- Positive Regulation Of Pyrroline-5-Carboxylate Reductase Activity
- Positive Regulation Of Tyrosine 3-Monooxygenase Activity
- Positive Regulation Of Dopamine Biosynthetic Process
- Glyoxal Metabolic Process
- Glyoxal Catabolic Process
- Positive Regulation Of L-Dopa Biosynthetic Process
- Positive Regulation Of L-Dopa Decarboxylase Activity
- Negative Regulation Of Oxidative Stress-Induced Cell Death
- Negative Regulation Of Hydrogen Peroxide-Induced Cell Death
- Negative Regulation Of Hydrogen Peroxide-Induced Neuron Death
- Negative Regulation Of Oxidative Stress-Induced Neuron Intrinsic Apoptotic Signaling Pathway
- Negative Regulation Of Hydrogen Peroxide-Induced Neuron Intrinsic Apoptotic Signaling Pathway
- Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
- Positive Regulation Of Mitophagy
- Negative Regulation Of Nitrosative Stress-Induced Intrinsic Apoptotic Signaling Pathway
- Negative Regulation Of Ubiquitin-Specific Protease Activity
- Positive Regulation Of Oxidative Phosphorylation Uncoupler Activity
- Positive Regulation Of Transcription Regulatory Region Dna Binding
- Positive Regulation Of Androgen Receptor Activity
- Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
- Negative Regulation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Signaling Pathway