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  3. PAPPA

PAPPA (Pappalysin 1)

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The Function of PAPPA

Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.

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Protein names

Recommended name:

Pappalysin-1

Short name:

PAPP-A

Alternative name(s):

Insulin-like growth factor-dependent IGF-binding protein 4 protease
IGF-dependent IGFBP-4 protease
IGFBP-4ase
Pregnancy-associated plasma protein A

PAPPA SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1003858 (PAPPA) ??
  2. RS17303101 (PAPPA) ??
  3. RS436582 (PAPPA) ??
  4. RS751543 (PAPPA) ??
  5. RS7869550 (PAPPA) ??

Top Gene-Substance Interactions

PAPPA Interacts with These Diseases

Disease Score

Substances That Increase PAPPA

Substances Interaction Organism Category

Substances That Decrease PAPPA

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • Sp1

Tissue specificity:

High levels in placenta and pregnancy serum. In placenta, expressed in X cells in septa and anchoring villi, and in syncytiotrophoblasts in the chorionic villi. Lower levels are found in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow, colon, fibroblasts and osteoblasts.

Gene Pathways:

  • Metabolism of proteins

Induction:

By 8-bromoadenosine-3',5'-phosphate.

Developmental stage:

Present in serum and placenta during pregnancy; levels increase throughout pregnancy.

Enzyme Regulation:

Inhibited by complexation with the proform of PRG2.

Cofactor:

Binds 1 zinc ion per subunit.

Molecular Function:

  • Metalloendopeptidase Activity
  • Metallopeptidase Activity
  • Zinc Ion Binding

Biological Processes:

  • Cellular Protein Metabolic Process
  • Female Pregnancy
  • Response To Follicle-Stimulating Hormone
  • Response To Glucocorticoid
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| PAPA| A306_06079| AS27_09050| AS28_06676| ASBABP2| aspecific BCL2 ARE-binding protein 2| CB1_001573001| cleaves insulin-like binding protein-4 (IGFBP-4)| D623_10028463| differentially placenta 1 expressed protein| DIPLA1| GW7_01800| H920_11884| I79_017279| IGFBP-4ase| IGF-dependent IGFBP-4 protease| insulin-like growth factor-dependent IGF binding protein-4 protease| insulin-like growth factor-dependent IGF-binding protein 4 protease| M91_17265| M959_02293| MDA_GLEAN10014438| metalloprotease| N300_08038| N301_12777| N302_08370| N303_06060| N305_03053| N307_12585| N309_09198| N310_05213| N311_05376| N312_05410| N321_11627| N324_02160| N325_01110| N326_08008| N327_08369| N328_04869| N330_03607| N332_14454| N333_12322| N334_05908| N335_01606| N336_03670| N339_11912| N340_12828| PAG1| PAL_GLEAN10009827| PANDA_003832| PAPP-A| PAPPA1| PAPPA-like protein| pappalysin-1| pregnacy-associated plasma protein A| pregnancy associated plasma protein A| pregnancy-associated plasma protein A| pregnancy-associated plasma protein-A| pregnancy-associated plasma protein A-like protein| pregnancy-associated plasma protein A, pappalysin 1| pregnancy-associated plasma protein Apappalysin 1| pregnancy-associated plasma protein A preproprotein-like protein| TREES_T100003853| UY3_04676| Y1Q_024616| Y956_15857| Z169_03837| pappa

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