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  3. PAM

PAM (Peptidylglycine alpha-amidating monooxygenase)

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The Function of PAM

Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity.

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Top Gene-Substance Interactions

PAM Interacts with These Diseases

Disease Score

Substances That Increase PAM

Substances Interaction Organism Category

Substances That Decrease PAM

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • GR
  • GR-alpha
  • GR-beta
  • NF-kappaB1
  • c-Myc

Enzyme Regulation:

Inhibited by EDTA, phenylglyoxal and diethyl pyrocarbonate.

Cofactor:

Binds 2 copper ions per subunit for the monoxygenase reaction.

Molecular Function:

  • Calcium Ion Binding
  • Copper Ion Binding
  • L-Ascorbic Acid Binding
  • Peptidylamidoglycolate Lyase Activity
  • Peptidylglycine Monooxygenase Activity
  • Zinc Ion Binding

Biological Processes:

  • Central Nervous System Development
  • Heart Development
  • Lactation
  • Limb Development
  • Long-Chain Fatty Acid Metabolic Process
  • Maternal Process Involved In Female Pregnancy
  • Odontogenesis
  • Ovulation Cycle Process
  • Peptide Amidation
  • Protein Amidation
  • Protein Homooligomerization
  • Regulation Of Actin Cytoskeleton Organization
  • Regulation Of Protein Secretion
  • Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Response To Copper Ion
  • Response To Estradiol
  • Response To Glucocorticoid
  • Response To Hypoxia
  • Response To Ph
  • Toxin Metabolic Process

Drug Bank:

  • Vitamin C
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AS27_13817| AS28_03193| CB1_000916039| D623_10033105| H920_01697| MDA_GLEAN10017536| N300_07870| N301_13472| N302_08959| N305_04001| N306_10074| N307_15312| N308_05517| N309_08099| N311_10610| N312_12562| N321_02808| N322_06949| N324_11577| N326_06898| N327_10521| N329_06196| N330_12321| N333_10741| N334_01974| N335_12724| N336_07861| N339_06510| N341_10093| pal| PAL_GLEAN10025007| pam-a| pam-b| pancreatic peptidylglycine alpha-amidating monooxygenase| PANDA_012223| peptidyl alpha-amidating enzyme| peptidyl-alpha-hydroxyglycine alpha-amidating lyase| peptidylamidoglycolate lyase| peptidylglycine 2-hydroxylase| Peptidyl-glycine alpha-amidating monooxygenase| Peptidyl-glycine alpha-amidating monooxygenase B| peptidyl-glycine alpha-amidating monooxygenase isoform a preproprotein| peptidyl-glycine alpha-amidating monooxygenase isoform b preproprotein| peptidyl-glycine alpha-amidating monooxygenase isoform c preproprotein| peptidyl-glycine alpha-amidating monooxygenase isoform e preproprotein| PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE PRECURSOR (PAM)| peptidylglycine alpha-hydroxylating monooxygenase| PHM| TREES_T100000014| UY3_10379| Y1Q_005226| Y956_02328| Z169_06222| pam

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