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  3. PACS1

PACS1 (Phosphofurin acidic cluster sorting protein 1)

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The Function of PACS1

Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN.

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Protein names

Recommended name:

Phosphofurin acidic cluster sorting protein 1

Short name:

PACS-1

PACS1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS524281 (PACS1) ??
  2. RS564343 (PACS1) ??

Top Gene-Substance Interactions

PACS1 Interacts with These Diseases

Disease Score

Substances That Increase PACS1

Substances Interaction Organism Category

Substances That Decrease PACS1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • AP-1
  • c-Jun

Gene Pathways:

  • Disease

Molecular Function:

  • Ion Channel Binding

Biological Processes:

  • Protein Targeting To Golgi
  • Protein Targeting To Plasma Membrane
  • Regulation Of Defense Response To Virus By Virus
  • Viral Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_07591| CB1_000429035| cytosolic sorting protein PACS-1| D623_10030755| H920_10240| I79_017593| M91_15907| MDA_GLEAN10017874| MRD17| Pacs-1| PAL_GLEAN10011342| phosphofurin acidic cluster sorting protein 1-like protein| phosphofurin acidic cluster sorting protein 2| SHMS| TREES_T100012677| UY3_03620| pacs1

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