The Function of PACS1
Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN.
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Protein names
Recommended name:
Phosphofurin acidic cluster sorting protein 1Short name:
PACS-1- RS524281 (PACS1) ??
- RS564343 (PACS1) ??
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Top Gene-Substance Interactions
PACS1 Interacts with These Diseases
| Disease | Score |
Substances That Increase PACS1
| Substances | Interaction | Organism | Category |
Substances That Decrease PACS1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
Biological Processes:
- Protein Targeting To Golgi
- Protein Targeting To Plasma Membrane
- Regulation Of Defense Response To Virus By Virus
- Viral Process