The Function of PABPC1
Binds the poly(A) tail of mRNA, including that of its own transcript. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability (PubMed:25480299). Positively regulates the replication of dengue virus (DENV) (PubMed:26735137).
Protein names
Recommended name:
Polyadenylate-binding protein 1Short name:
PABP-1Alternative name(s):
Poly(A- RS1693575 (PABPC1) ??
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Top Gene-Substance Interactions
PABPC1 Interacts with These Diseases
| Disease | Score |
Substances That Increase PABPC1
| Substances | Interaction | Organism | Category |
Substances That Decrease PABPC1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Ubiquitous.
Gene Pathways:
Caution:
Was termed (Ref.5) polyadenylate binding protein II.
Molecular Function:
- Mrna 3'-Utr Binding
- Nucleotide Binding
- Poly(A) Binding
- Poly(A) Rna Binding
- Poly(U) Rna Binding
- Protein C-Terminus Binding
- Translation Activator Activity
Biological Processes:
- Gene Silencing By Rna
- Mrna Polyadenylation
- Mrna Splicing, Via Spliceosome
- Mrna Stabilization
- Negative Regulation Of Nuclear-Transcribed Mrna Catabolic Process, Nonsense-Mediated Decay
- Nuclear-Transcribed Mrna Catabolic Process, Nonsense-Mediated Decay
- Nuclear-Transcribed Mrna Poly(A) Tail Shortening
- Positive Regulation Of Nuclear-Transcribed Mrna Catabolic Process, Deadenylation-Dependent Decay
- Positive Regulation Of Nuclear-Transcribed Mrna Poly(A) Tail Shortening
- Positive Regulation Of Viral Genome Replication
- Regulation Of Mrna Stability
- Translational Initiation