The Function of PA2G4
May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation.
Protein names
Recommended name:
Proliferation-associated protein 2G4Alternative name(s):
Cell cycle protein p38-2G4 homologhG4-1
ErbB3-binding protein 1
Top Gene-Substance Interactions
PA2G4 Interacts with These Diseases
| Disease | Score |
Substances That Increase PA2G4
| Substances | Interaction | Organism | Category |
Substances That Decrease PA2G4
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Isoform 2 is undetectable whereas isoform 1 is strongly expressed in cancer cells (at protein level). Isoform 1 and isoform 2 are widely expressed, including heart, brain, lung, pancreas, skeletal muscle, kidney, placenta and liver.
Caution:
Although it belongs to the peptidase M24 family, it does not contain metal cofactors and lacks aminopeptidase activity.
Molecular Function:
- Dna Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Ubiquitin Protein Ligase Binding
- Poly(A) Rna Binding
Biological Processes:
- Transcription, Dna-Templated
- Rrna Processing
- Regulation Of Translation
- Cell Cycle Arrest
- Cell Proliferation
- Negative Regulation Of Apoptotic Process
- Positive Regulation Of Cell Differentiation
- Negative Regulation Of Transcription, Dna-Templated