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  3. PA2G4

PA2G4 (Proliferation-associated 2G4)

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The Function of PA2G4

May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation.

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Protein names

Recommended name:

Proliferation-associated protein 2G4

Alternative name(s):

Cell cycle protein p38-2G4 homolog
hG4-1
ErbB3-binding protein 1

Top Gene-Substance Interactions

PA2G4 Interacts with These Diseases

Disease Score

Substances That Increase PA2G4

Substances Interaction Organism Category

Substances That Decrease PA2G4

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • E2F-1

Tissue specificity:

Isoform 2 is undetectable whereas isoform 1 is strongly expressed in cancer cells (at protein level). Isoform 1 and isoform 2 are widely expressed, including heart, brain, lung, pancreas, skeletal muscle, kidney, placenta and liver.

Caution:

Although it belongs to the peptidase M24 family, it does not contain metal cofactors and lacks aminopeptidase activity.

Molecular Function:

  • Dna Binding
  • Poly(A) Rna Binding
  • Transcription Factor Activity, Sequence-Specific Dna Binding
  • Ubiquitin Protein Ligase Binding

Biological Processes:

  • Cell Cycle Arrest
  • Cell Proliferation
  • Negative Regulation Of Apoptotic Process
  • Negative Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Cell Differentiation
  • Regulation Of Translation
  • Rrna Processing
  • Transcription, Dna-Templated
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 38kDa| mpp1| A306_09157| Anapl_18426| AS27_12151| AS28_00660| CB1_000449019| cell cycle protein p38-2G4 homolog| EBP1| ErbB-3 binding protein 1| ErbB3-binding protein 1| ErbB3-binding protein Ebp1| H920_14064| hg4-1| IRES-specific cellular trans-acting factor 45 kDa| ITAF45| M91_19724| M959_06130| N300_05582| N301_10099| N302_03604| N303_15746| N305_07841| N306_00889| N308_02371| N309_15412| N310_08761| N312_05437| N322_08910| N327_03994| N328_08687| N329_03155| N331_06359| N332_05841| N334_03712| N335_11300| N339_08573| N340_07520| N341_07945| p38-2g4| PAL_GLEAN10004811| PANDA_004075| Plfap| proliferation-associated 2G4, 38kD| proliferation-associated 2G4, 38kDa| proliferation-associated protein 1| Proliferation-associated protein 2G4| proliferation-associated protein 2G4-like protein| protein p38-2G4| TREES_T100006942| Y1Q_007579| Y956_11566| pa2g4

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