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  3. OPRK1

OPRK1 (Opioid receptor kappa 1)

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The Function of OPRK1

G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.

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Protein names

Recommended name:

Kappa-type opioid receptor

Short name:

KOR-1

Alternative name(s):

K-OR-1

OPRK1 SNPs

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  1. RS702764 (OPRK1) ??

Top Gene-Substance Interactions

OPRK1 Interacts with These Diseases

Disease Score

Substances That Increase OPRK1

Substances Interaction Organism Category

Substances That Decrease OPRK1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • AP-1
  • Max
  • c-Jun
  • Nkx2-5
  • c-Myc
  • Sp1

Tissue specificity:

Detected in brain and placenta.

Gene Pathways:

  • Signal Transduction
  • Neuroactive ligand-receptor interaction

Molecular Function:

  • Dynorphin Receptor Activity
  • Neuropeptide Binding
  • Opioid Receptor Activity

Biological Processes:

  • Adenylate Cyclase-Inhibiting G-Protein Coupled Receptor Signaling Pathway
  • Adenylate Cyclase-Inhibiting Opioid Receptor Signaling Pathway
  • Behavior
  • Behavioral Response To Cocaine
  • Cellular Response To Lipopolysaccharide
  • Chemical Synaptic Transmission
  • Conditioned Place Preference
  • Defense Response To Virus
  • Eating Behavior
  • Estrous Cycle
  • Immune Response
  • Locomotory Behavior
  • Maternal Behavior
  • Negative Regulation Of Luteinizing Hormone Secretion
  • Neuropeptide Signaling Pathway
  • Opioid Receptor Signaling Pathway
  • Phospholipase C-Activating G-Protein Coupled Receptor Signaling Pathway
  • Positive Regulation Of Dopamine Secretion
  • Positive Regulation Of Locomotion
  • Positive Regulation Of P38mapk Cascade
  • Positive Regulation Of Potassium Ion Transmembrane Transport
  • Regulation Of Aerobic Respiration
  • Regulation Of Energy Homeostasis
  • Regulation Of Saliva Secretion
  • Regulation Of Sensory Perception Of Pain
  • Response To Acrylamide
  • Response To Estrogen
  • Response To Ethanol
  • Response To Insulin
  • Response To Morphine
  • Response To Radiation
  • Sensory Perception
  • Sensory Perception Of Pain
  • Sensory Perception Of Temperature Stimulus

Drug Bank:

  • Pethidine
  • Amitriptyline
  • Buprenorphine
  • Butorphanol
  • Codeine
  • Dextromethorphan
  • Dezocine
  • Eluxadoline
  • Fentanyl
  • Heroin
  • Hydromorphone
  • Ketamine
  • Ketobemidone
  • Levorphanol
  • Menthol
  • Methylnaltrexone
  • Mianserin
  • Mirtazapine
  • Nalbuphine
  • Naloxone
  • Naltrexone
  • Oxycodone
  • Progesterone
  • Remifentanil
  • Sufentanil
  • Tapentadol
  • Tramadol
  • Alvimopan
  • Dextropropoxyphene
  • Loperamide
  • Morphine
  • Pentazocine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Anapl_18022| AS27_01779| AS28_15115| CB1_001437028| EH28_19927| GW7_03075| H920_01157| I79_016575| kappa opioid receptor| kappa-type opioid receptor| kappa-type opioid receptor 1| kappa-type opioid receptor-like protein| kor| K-OR-1| KOR-1| M959_00891| MDA_GLEAN10024587| MSL-1| N300_12877| N301_08785| N302_13354| N303_05048| N305_08723| N306_12395| N307_02285| N308_01250| N309_03401| N310_00997| N311_11670| N312_05537| N320_01235| N321_05868| N324_09713| N325_03256| N326_01744| N327_07911| N328_00493| N329_11373| N330_01024| N331_04738| N332_01580| N333_04571| N334_00131| N335_01386| N336_06938| N339_05505| N340_10183| N341_10626| Opiate receptor, kappa-1| opioid receptor, kappa 1| opioid receptor, kappa 2| OPRK| Oprk2| ORK1| PAL_GLEAN10019243| PANDA_018979| R21| TREES_T100014547| UY3_11079| Y1Q_007885| Y956_15605| Z169_08708| ZfKOR| ZFOR3| oprk1

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