The Function of OPRK1

G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.

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Protein names

Recommended name:

Kappa-type opioid receptor

Short name:

KOR-1

Alternative name(s):

K-OR-1

Top Gene-Substance Interactions

OPRK1 Interacts with These Diseases

Substances That Increase OPRK1

Substances That Decrease OPRK1

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical