The Function of OPRK1
G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
Protein names
Recommended name:
Kappa-type opioid receptorShort name:
KOR-1Alternative name(s):
K-OR-1- RS702764 (OPRK1) ??
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Top Gene-Substance Interactions
OPRK1 Interacts with These Diseases
| Disease | Score |
Substances That Increase OPRK1
| Substances | Interaction | Organism | Category |
Substances That Decrease OPRK1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Detected in brain and placenta.
Gene Pathways:
Molecular Function:
Biological Processes:
- Adenylate Cyclase-Inhibiting G-Protein Coupled Receptor Signaling Pathway
- Adenylate Cyclase-Inhibiting Opioid Receptor Signaling Pathway
- Behavior
- Behavioral Response To Cocaine
- Cellular Response To Lipopolysaccharide
- Chemical Synaptic Transmission
- Conditioned Place Preference
- Defense Response To Virus
- Eating Behavior
- Estrous Cycle
- Immune Response
- Locomotory Behavior
- Maternal Behavior
- Negative Regulation Of Luteinizing Hormone Secretion
- Neuropeptide Signaling Pathway
- Opioid Receptor Signaling Pathway
- Phospholipase C-Activating G-Protein Coupled Receptor Signaling Pathway
- Positive Regulation Of Dopamine Secretion
- Positive Regulation Of Locomotion
- Positive Regulation Of P38mapk Cascade
- Positive Regulation Of Potassium Ion Transmembrane Transport
- Regulation Of Aerobic Respiration
- Regulation Of Energy Homeostasis
- Regulation Of Saliva Secretion
- Regulation Of Sensory Perception Of Pain
- Response To Acrylamide
- Response To Estrogen
- Response To Ethanol
- Response To Insulin
- Response To Morphine
- Response To Radiation
- Sensory Perception
- Sensory Perception Of Pain
- Sensory Perception Of Temperature Stimulus
Drug Bank:
- Pethidine
- Amitriptyline
- Buprenorphine
- Butorphanol
- Codeine
- Dextromethorphan
- Dezocine
- Eluxadoline
- Fentanyl
- Heroin
- Hydromorphone
- Ketamine
- Ketobemidone
- Levorphanol
- Menthol
- Methylnaltrexone
- Mianserin
- Mirtazapine
- Nalbuphine
- Naloxone
- Naltrexone
- Oxycodone
- Progesterone
- Remifentanil
- Sufentanil
- Tapentadol
- Tramadol
- Alvimopan
- Dextropropoxyphene
- Loperamide
- Morphine
- Pentazocine