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  3. OLFML3

OLFML3 (Olfactomedin like 3)

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The Function of OLFML3

Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes.

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Protein names

Recommended name:

Olfactomedin-like protein 3

Alternative name(s):

HNOEL-iso
hOLF44

OLFML3 SNPs

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  1. RS79079833 (OLFML3) ??

Top Gene-Substance Interactions

Substances That Increase OLFML3

Substances Interaction Organism Category

Substances That Decrease OLFML3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • ER-alpha
  • PPAR-gamma1
  • HNF-1A
  • PPAR-gamma2
  • HNF-1

Tissue specificity:

Abundant in placenta, moderate in liver and heart, whereas fairly weak in other tissues examined. On term placenta, mainly localized extracellularly surrounding the syncytiotrophoblastic cells and very rarely expressed in the maternal decidua layer.

Biological Processes:

  • Multicellular Organism Development
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| CB1_001984007| EGK_01117| EH28_08812| H920_08272| HNOEL-iso| I79_013079| M91_03162| MDA_GLEAN10024802| mONT3| N305_03355| N311_07764| N321_09846| N332_00726| olf44| olfactomedin-like 3| olfactomedin-like protein| Olfactomedin-like protein 3| Olfactomedin-like protein 3A| Olfactomedin-Noelin-Tiarin factor 1| ONT1| ONT3| PAL_GLEAN10017425| PANDA_006713| TREES_T100005424| UY3_06860| olfml3

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