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  3. OLFM4

OLFM4 (Olfactomedin 4)

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The Function of OLFM4

May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin.

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Protein names

Recommended name:

Olfactomedin-4

Short name:

OLM4

Alternative name(s):

Antiapoptotic protein GW112
G-CSF-stimulated clone 1 protein
hGC-1
hOLfD

OLFM4 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1343607 (OLFM4) ??
  2. RS2246208 (OLFM4) ??
  3. RS2806933 (OLFM4) ??
  4. RS2806946 (OLFM4) ??
  5. RS2806949 (OLFM4) ??
  6. RS2806971 (OLFM4) ??
  7. RS2806974 (OLFM4) ??
  8. RS732949 (OLFM4) ??
  9. RS8000124 (OLFM4) ??
  10. RS9536318 (OLFM4) ??
  11. RS9568797 (OLFM4) ??

Top Gene-Substance Interactions

Substances That Increase OLFM4

Substances Interaction Organism Category

Substances That Decrease OLFM4

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Nkx3-1 v1
  • Nkx3-1
  • NCX/Ncx

Tissue specificity:

Expressed during myeloid lineage development. Much higher expression in bone marrow neutrophils than in peripheral blood neutrophils (at protein level). Strongly expressed in the prostate, small intestine and colon and moderately expressed in the bone marrow and stomach. Overexpressed in some pancreatic cancer tissues.

Induction:

By retinoic acid. This induction requires functional NFKB pathway.

Developmental stage:

Elevated expression during the early S phase of the cell cycle, followed by a gradual decrease during late S phase.

Molecular Function:

  • Cadherin Binding
  • Catalytic Activity
  • Protein Homodimerization Activity

Biological Processes:

  • Cell Adhesion
  • Positive Regulation Of Substrate Adhesion-Dependent Cell Spreading
  • Protein Homooligomerization
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Anapl_11789| antiapoptotic protein GW112| AS27_03688| AS28_13776| bA209J19.1| CB1_000258035| GC1| G-CSF-stimulated clone 1 protein| GW112| GW7_06274| H920_10702| hGC-1| hOLfD| M91_19310| N300_02320| N301_05962| N303_02254| N305_09732| N306_06220| N308_11788| N309_12791| N311_01834| N320_11212| N324_12015| N325_08353| N328_07810| N329_10355| N340_13507| N341_04197| olfactomedin-4| olfactomedin-4-like protein| OlfD| OLM4| PAL_GLEAN10015242| PANDA_003938| pPD4| PU.1 difference product 4| tiarin| TREES_T100021613| UNQ362| Y1Q_025945| Y956_10232| Z169_15226| olfm4

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