The Function of OLFM4
May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin.
Protein names
Recommended name:
Olfactomedin-4Short name:
OLM4Alternative name(s):
Antiapoptotic protein GW112G-CSF-stimulated clone 1 protein
hGC-1
hOLfD
- RS1343607 (OLFM4) ??
- RS2246208 (OLFM4) ??
- RS2806933 (OLFM4) ??
- RS2806946 (OLFM4) ??
- RS2806949 (OLFM4) ??
- RS2806971 (OLFM4) ??
- RS2806974 (OLFM4) ??
- RS732949 (OLFM4) ??
- RS8000124 (OLFM4) ??
- RS9536318 (OLFM4) ??
- RS9568797 (OLFM4) ??
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Top Gene-Substance Interactions
Substances That Increase OLFM4
| Substances | Interaction | Organism | Category |
Substances That Decrease OLFM4
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed during myeloid lineage development. Much higher expression in bone marrow neutrophils than in peripheral blood neutrophils (at protein level). Strongly expressed in the prostate, small intestine and colon and moderately expressed in the bone marrow and stomach. Overexpressed in some pancreatic cancer tissues.
Induction:
By retinoic acid. This induction requires functional NFKB pathway.
Developmental stage:
Elevated expression during the early S phase of the cell cycle, followed by a gradual decrease during late S phase.
Molecular Function:
Biological Processes:
- Cell Adhesion
- Protein Homooligomerization
- Positive Regulation Of Substrate Adhesion-Dependent Cell Spreading