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  3. ODC1

ODC1 (Ornithine decarboxylase 1)

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Summary of ODC1

ODC1 codes for a rate-limiting enzyme that is used to control the production of putrescine. [R] The production of which has been shown to cause a bad smelling odor. Wich has been associated with bad breath, bacterial vaginosis, and decaying flesh. [R]

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The Function of ODC1

Key enzyme of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine.

Protein names

Recommended name:

Ornithine decarboxylase

Short name:

ODC

ODC1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2302615 (ODC1) ??

Top Gene-Substance Interactions

ODC1 Interacts with These Diseases

Disease Score

Substances That Increase ODC1

Substances Interaction Organism Category

Substances That Decrease ODC1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Glutathione metabolism
  • Arginine and proline metabolism

Induction:

Down-regulated in response to enterovirus 71 (EV71) infection (at protein level).

Enzyme Regulation:

Inhibited by S-nitrosylation. Inhibited by antizyme OAZ1, OAZ2 and OAZ3.

Molecular Function:

  • Ornithine Decarboxylase Activity
  • Protein Homodimerization Activity

Biological Processes:

  • Kidney Development
  • Polyamine Metabolic Process
  • Positive Regulation Of Cell Proliferation
  • Putrescine Biosynthetic Process From Ornithine
  • Regulation Of Cellular Amino Acid Metabolic Process
  • Regulation Of Protein Catabolic Process
  • Response To Virus

Drug Bank:

  • Eflornithine
  • Spermine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Anapl_08381| AS27_15670| AS28_03586| CB1_001616081| CG8721 gene product from transcript CG8721-RA| CG8721-PA| CHUNP6922| DCOR1| Dmel_CG8721| dodc1| EH28_01028| fc54f04| fi06d08| GW7_13021| H920_07395| M959_14782| MDA_GLEAN10012557| N300_15335| N301_06694| N302_01875| N303_09050| N305_01615| N306_06099| N307_06766| N308_13719| N309_12034| N310_01009| N311_02607| N312_05262| N320_10324| N321_13659| N322_10785| N324_10913| N325_12675| N326_07484| N327_00418| N328_08489| N329_04732| N330_01767| N331_05258| N332_10257| N333_12323| N334_10802| N336_03606| N339_12001| N340_04510| OD| ODC| Odc-1| Odc1-PA| odc2| ornithine decarboxylase| ornithine decarboxylase-1| ornithine decarboxylase-like protein| ornithine decarboxylase, structural 1| Ornitine decarboxylase| PAL_GLEAN10020130| PANDA_010453| TREES_T100010470| UY3_00718| xODC1| xodc2| Y1Q_019124| Y956_15350| Z169_02356| odc1

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