Summary of ODC1
ODC1 codes for a rate-limiting enzyme that is used to control the production of putrescine. [R] The production of which has been shown to cause a bad smelling odor. Wich has been associated with bad breath, bacterial vaginosis, and decaying flesh. [R]
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The Function of ODC1
Key enzyme of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine.
Protein names
Recommended name:
Ornithine decarboxylaseShort name:
ODC- RS2302615 (ODC1) ??
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Top Gene-Substance Interactions
ODC1 Interacts with These Diseases
| Disease | Score |
Substances That Increase ODC1
| Substances | Interaction | Organism | Category |
Substances That Decrease ODC1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Induction:
Down-regulated in response to enterovirus 71 (EV71) infection (at protein level).
Enzyme Regulation:
Inhibited by S-nitrosylation. Inhibited by antizyme OAZ1, OAZ2 and OAZ3.
Molecular Function:
Biological Processes:
- Kidney Development
- Regulation Of Cellular Amino Acid Metabolic Process
- Polyamine Metabolic Process
- Positive Regulation Of Cell Proliferation
- Response To Virus
- Putrescine Biosynthetic Process From Ornithine
- Regulation Of Protein Catabolic Process
Drug Bank:
- Eflornithine
- Spermine