Summary of NUDT1
The gene codes for a protein, nudix hydrolase 1. It can cause mutations that may result in carcinogenesis or neurodegeneration [R].
The Function of NUDT1
Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.
Protein names
Recommended name:
7,8-dihydro-8-oxoguanine triphosphataseAlternative name(s):
2-hydroxy-dATP diphosphatase8-oxo-dGTPase
Nucleoside diphosphate-linked moiety X motif 1
Nudix motif 1
- RS4866 (NUDT1) ??
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Top Gene-Substance Interactions
NUDT1 Interacts with These Diseases
| Disease | Score |
Substances That Increase NUDT1
| Substances | Interaction | Organism | Category |
Substances That Decrease NUDT1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes.
Developmental stage:
In peripheral blood lymphocytes, expressed at much higher levels in proliferating cells than in resting cells.
Enzyme Regulation:
2-hydroxy-dATPase activity is inhibited by 2-OH-dADP, 8-OH-dGDP and 8-OH-dGTP. 8-OH-dGTPase activity is inhibited by 8-OH-dGDP, 2-OH-dADP and 2-OH-dATP.
Cofactor:
Binds 1 Mg(2+) ion per subunit.
Molecular Function:
- Gtpase Activity
- 8-Oxo-7,8-Dihydroguanosine Triphosphate Pyrophosphatase Activity
- Snorna Binding
- Metal Ion Binding
- 2-Hydroxy-(Deoxy)Adenosine-Triphosphate Pyrophosphatase Activity
- 2-Hydroxy-Adenosine Triphosphate Pyrophosphatase Activity
- 8-Oxo-7,8-Dihydrodeoxyguanosine Triphosphate Pyrophosphatase Activity
- Atp Diphosphatase Activity
- Gtp Diphosphatase Activity
Biological Processes:
- Purine Nucleotide Catabolic Process
- Dgtp Catabolic Process
- Dna Repair
- Response To Oxidative Stress
- Aging
- Male Gonad Development
- Nucleobase-Containing Small Molecule Catabolic Process
- Dna Protection
- Datp Catabolic Process
- Response To Cadmium Ion