• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. NUDT1

NUDT1 (Nudix hydrolase 1)

Loading...

Summary of NUDT1

The gene codes for a protein, nudix hydrolase 1. It can cause mutations that may result in carcinogenesis or neurodegeneration [R].

0 users want this gene increased, 0 users want it decreased

The Function of NUDT1

Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.

Protein names

Recommended name:

7,8-dihydro-8-oxoguanine triphosphatase

Alternative name(s):

2-hydroxy-dATP diphosphatase
8-oxo-dGTPase
Nucleoside diphosphate-linked moiety X motif 1
Nudix motif 1

NUDT1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS4866 (NUDT1) ??

Top Gene-Substance Interactions

NUDT1 Interacts with These Diseases

Disease Score

Substances That Increase NUDT1

Substances Interaction Organism Category

Substances That Decrease NUDT1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha
  • GR-beta

Tissue specificity:

Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes.

Developmental stage:

In peripheral blood lymphocytes, expressed at much higher levels in proliferating cells than in resting cells.

Enzyme Regulation:

2-hydroxy-dATPase activity is inhibited by 2-OH-dADP, 8-OH-dGDP and 8-OH-dGTP. 8-OH-dGTPase activity is inhibited by 8-OH-dGDP, 2-OH-dADP and 2-OH-dATP.

Cofactor:

Binds 1 Mg(2+) ion per subunit.

Molecular Function:

  • 2-Hydroxy-(Deoxy)Adenosine-Triphosphate Pyrophosphatase Activity
  • 2-Hydroxy-Adenosine Triphosphate Pyrophosphatase Activity
  • 8-Oxo-7,8-Dihydrodeoxyguanosine Triphosphate Pyrophosphatase Activity
  • 8-Oxo-7,8-Dihydroguanosine Triphosphate Pyrophosphatase Activity
  • Atp Diphosphatase Activity
  • Gtpase Activity
  • Gtp Diphosphatase Activity
  • Metal Ion Binding
  • Snorna Binding

Biological Processes:

  • Aging
  • Datp Catabolic Process
  • Dgtp Catabolic Process
  • Dna Protection
  • Dna Repair
  • Male Gonad Development
  • Nucleobase-Containing Small Molecule Catabolic Process
  • Purine Nucleotide Catabolic Process
  • Response To Cadmium Ion
  • Response To Oxidative Stress
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 2-hydroxy-dATP diphosphatase| 7,8-dihydro-8-oxoguanine triphosphatase| 7,8-dihydro-8-oxoguanine triphosphatase isoform p22| 8odp| 8-oxo-7,8-dihydro-2'-dGTPase| 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase| 8-oxo-7,8-dihydroguanosine triphosphatase| 8-oxo-dGTPase| A306_02713| AS27_12248| AS28_05878| CB1_000114012| EGK_13416| EH28_20696| GW7_16889| H920_18540| I79_001693| M91_16361| M959_02563| MDA_GLEAN10021498| mth1| mutT human homolog 1| mutT human homolog (8-oxo-dGTPase)| N300_09834| N301_10475| N302_11857| N303_07096| N305_14839| N306_04162| N307_07740| N308_12258| N309_08220| N310_03665| N311_08151| N320_03760| N321_00822| N325_03506| N326_09900| N327_09338| N328_04616| N329_07004| N330_02038| N331_09784| N332_06670| N333_12942| N335_13967| N336_04095| N339_10652| N340_01635| nucleoside diphosphate-linked moiety X motif 1| nucleoside diphosphate-linked moiety X-type motif 1| nudix motif 1| nudix (nucleoside diphosphate linked moiety X)-type motif 1| nudix -type motif 1| nudix-type motif 1| PANDA_021049| UY3_12241| Y1Q_011789| Y956_00573| Z169_07113| nudt1

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved