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  3. NUCB2

NUCB2 (Nucleobindin 2)

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Summary of NUCB2

The gene codes for a protein, nucleobindin 2. It plays a role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells [R].

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The Function of NUCB2

Nesfatin-1: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance.

Protein names

Recommended name:

Nucleobindin-2

Alternative name(s):

DNA-binding protein NEFA
Gastric cancer antigen Zg4
Prepronesfatin

NUCB2 SNPs

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  1. RS1330 (NUCB2) ??

Top Gene-Substance Interactions

NUCB2 Interacts with These Diseases

Disease Score

Substances That Increase NUCB2

Substances Interaction Organism Category

Substances That Decrease NUCB2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • NF-kappaB1
  • PPAR-alpha
  • HNF-4alpha1
  • HNF-4alpha2
  • SREBP-1a
  • c-Rel
  • SREBP-1c
  • SREBP-1b

Tissue specificity:

Predominantly expressed in spleen, testis and normal stomach.

Molecular Function:

  • Calcium Ion Binding
  • Dna Binding
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| p54| Anapl_14747| AS27_14492| Calnuc| CB1_056579125| DNA-binding protein NEFA| epididymis secretory protein Li 109| gastric cancer antigen Zg4| H920_19886| HEL-S-109| M91_10982| M959_15055| MDA_GLEAN10000958| N300_06517| N302_13676| N307_13518| N308_14228| N310_10849| N320_04273| N321_02553| N324_09768| N330_14281| N333_13448| N335_11216| N336_06406| N339_08452| nefa| nesfatin 1| nesfatin-1| Nucleobindin-2| nucleobindin-2-like protein| Nucleobindin 2 precursor isoform 2-like protein| nucleobinding 2| PAL_GLEAN10004336| PANDA_014635| prepronefastin| prepronesfatin| TREES_T100011556| Y956_06773| Z169_01637| nucb2

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