The Function of NUAK1
Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate to transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316).
Protein names
Recommended name:
NUAK family SNF1-like kinase 1Short name:
ARK5Alternative name(s):
AMPK-related protein kinase 5Omphalocele kinase 1
- RS6539247 (NUAK1) ??
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Top Gene-Substance Interactions
NUAK1 Interacts with These Diseases
| Disease | Score |
Substances That Increase NUAK1
| Substances | Interaction | Organism | Category |
Substances That Decrease NUAK1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed at high levels in heart and brain, and at lower levels in skeletal muscle, kidney, ovary, placenta, lung and liver. Highly up-regulated in colorectal cancer cell lines.
Induction:
Transcriptionally regulated by members of the MAF family.
Enzyme Regulation:
Activated by phosphorylation on Thr-211. Activated by phosphorylation at Ser-600 AKT1 during glucose starvation; the relevance of such activation in normal cells is however unsure.
Molecular Function:
Biological Processes:
- Cell Adhesion
- Cellular Response To Dna Damage Stimulus
- Intracellular Signal Transduction
- Protein Phosphorylation
- Regulation Of Cell Adhesion
- Regulation Of Cell Proliferation
- Regulation Of Cellular Senescence
- Regulation Of Myosin-Light-Chain-Phosphatase Activity
- Regulation Of Signal Transduction By P53 Class Mediator